Department of Surgery,
Department of Pathology & Immunology
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Murine vascular endothelium activates and induces the generation of allogeneic CD4+25+Foxp3+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2005 | Pubmed ID: 16272276
Orthotopic mouse lung transplantation as experimental methodology to study transplant and tumor biology.
Nature protocols , 2009 | Pubmed ID: 19131960
Apyrase treatment prevents ischemia-reperfusion injury in rat lung isografts.
The Journal of thoracic and cardiovascular surgery Sep, 2009 | Pubmed ID: 19698866
Strain-specific susceptibility for pulmonary metastasis of sarcoma 180 cells in inbred mice.
Cancer research Jun, 2010 | Pubmed ID: 20501835
Cutting edge: MHC class II expression by pulmonary nonhematopoietic cells plays a critical role in controlling local inflammatory responses.
Journal of immunology (Baltimore, Md. : 1950) Oct, 2010 | Pubmed ID: 20810992
Bcl3 prevents acute inflammatory lung injury in mice by restraining emergency granulopoiesis.
The Journal of clinical investigation Jan, 2011 | Pubmed ID: 21157041
Maintenance of IKKβ activity is necessary to protect lung grafts from acute injury.
Transplantation Mar, 2011 | Pubmed ID: 21293322
Emergency granulopoiesis promotes neutrophil-dendritic cell encounters that prevent mouse lung allograft acceptance.
Blood Dec, 2011 | Pubmed ID: 21972291
Neutrophils are required for 3-methylcholanthrene-initiated, butylated hydroxytoluene-promoted lung carcinogenesis.
Molecular carcinogenesis Dec, 2012 | Pubmed ID: 22006501
HIF-1α signaling by airway epithelial cell K-α1-tubulin: role in fibrosis and chronic rejection of human lung allografts.
Cellular immunology , 2012 | Pubmed ID: 22192476
Intravital 2-photon imaging of leukocyte trafficking in beating heart.
The Journal of clinical investigation Jul, 2012 | Pubmed ID: 22706307
Strain-specific variation in murine natural killer gene complex contributes to differences in immunosurveillance for urethane-induced lung cancer.
Cancer research Sep, 2012 | Pubmed ID: 22751136
Five-year update on the mouse model of orthotopic lung transplantation: Scientific uses, tricks of the trade, and tips for success.
Journal of thoracic disease Jun, 2012 | Pubmed ID: 22754663
Complement activation is not required for obliterative airway disease induced by antibodies to major histocompatibility complex class I: Implications for chronic lung rejection.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation Nov, 2012 | Pubmed ID: 22980951
Cutting edge: Pseudomonas aeruginosa abolishes established lung transplant tolerance by stimulating B7 expression on neutrophils.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2012 | Pubmed ID: 23018463
Surgical technique for lung retransplantation in the mouse.
Journal of thoracic disease Jun, 2013 | Pubmed ID: 23825768
Increased T cell glucose uptake reflects acute rejection in lung grafts.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Oct, 2013 | Pubmed ID: 23927673
Hyaluronan contributes to bronchiolitis obliterans syndrome and stimulates lung allograft rejection through activation of innate immunity.
American journal of respiratory and critical care medicine Mar, 2014 | Pubmed ID: 24471427
Human recombinant apyrase therapy protects against canine pulmonary ischemia-reperfusion injury.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation Feb, 2015 | Pubmed ID: 25455749
De novo-developed antibodies to donor MHC antigens lead to dysregulation of microRNAs and induction of MHC class II.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2015 | Pubmed ID: 25941328
The Role of Lymphoid Neogenesis in Allografts.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Apr, 2016 | Pubmed ID: 26614734
Noninvasive Imaging of CCR2 Cells in Ischemia-Reperfusion Injury After Lung Transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 10, 2016 | Pubmed ID: 27273836
The Role of Neutrophils in Transplanted Organs.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 02, 2017 | Pubmed ID: 27344051
Heart-resident CCR2 macrophages promote neutrophil extravasation through TLR9/MyD88/CXCL5 signaling.
JCI insight Aug, 2016 | Pubmed ID: 27536731
CD36 deficiency impairs the small intestinal barrier and induces subclinical inflammation in mice.
Cellular and molecular gastroenterology and hepatology Jan, 2017 | Pubmed ID: 28066800
Deficiency of the adaptor protein SLy1 results in a natural killer cell ribosomopathy affecting tumor clearance.
Oncoimmunology , 2016 | Pubmed ID: 28123874
Models of Lung Transplant Research: a consensus statement from the National Heart, Lung, and Blood Institute workshop.
JCI insight May, 2017 | Pubmed ID: 28469087
Zbtb7a induction in alveolar macrophages is implicated in anti-HLA-mediated lung allograft rejection.
Science translational medicine Jul, 2017 | Pubmed ID: 28701473
Report of the ISHLT Working Group on Primary Lung Graft Dysfunction Part III: Mechanisms: A 2016 Consensus Group Statement of the International Society for Heart and Lung Transplantation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 10, 2017 | Pubmed ID: 28818404
Mechanisms of Graft Rejection and Immune Regulation after Lung Transplant.
Annals of the American Thoracic Society Sep, 2017 | Pubmed ID: 28945475
Naive CD4 T Cells Carrying a TLR2 Agonist Overcome TGF-β-Mediated Tumor Immune Evasion.
Journal of immunology (Baltimore, Md. : 1950) 01, 2018 | Pubmed ID: 29212908
Visualization of Monocytic Cells in Regressing Atherosclerotic Plaques by Intravital 2-Photon and Positron Emission Tomography-Based Imaging-Brief Report.
Arteriosclerosis, thrombosis, and vascular biology 05, 2018 | Pubmed ID: 29567678
Diagnosis, Pathophysiology and Experimental Models of Chronic Lung Allograft Rejection.
Transplantation 09, 2018 | Pubmed ID: 29683998
Spleen-derived classical monocytes mediate lung ischemia-reperfusion injury through IL-1β.
The Journal of clinical investigation Jul, 2018 | Pubmed ID: 29781811
Neutrophil extracellular trap fragments stimulate innate immune responses that prevent lung transplant tolerance.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 04, 2019 | Pubmed ID: 30378766
Bronchus-associated lymphoid tissue-resident Foxp3+ T lymphocytes prevent antibody-mediated lung rejection.
The Journal of clinical investigation 02, 2019 | Pubmed ID: 30561386
Mitochondrial damage-associated molecular patterns released by lung transplants are associated with primary graft dysfunction.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 05, 2019 | Pubmed ID: 30582269
An obligatory role for club cells in preventing obliterative bronchiolitis in lung transplants.
JCI insight 04, 2019 | Pubmed ID: 30990794
Pseudomonas aeruginosa and acute rejection independently increase the risk of donor-specific antibodies after lung transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 04, 2020 | Pubmed ID: 31677358
Perfect timing: circadian rhythms, sleep, and immunity - an NIH workshop summary.
JCI insight 01, 2020 | Pubmed ID: 31941836
Recent advances into the role of pattern recognition receptors in transplantation.
Cellular immunology 05, 2020 | Pubmed ID: 32183988
Local complement activation is associated with primary graft dysfunction after lung transplantation.
JCI insight 09, 2020 | Pubmed ID: 32750037
Pericardial Mitochondrial DNA Levels Are Associated With Atrial Fibrillation After Cardiac Surgery.
The Annals of thoracic surgery 05, 2021 | Pubmed ID: 32946846
Galuminox: Preclinical validation of a novel PET tracer for non-invasive imaging of oxidative stress in vivo.
Redox biology 10, 2020 | Pubmed ID: 33039825
Lymphatic drainage from bronchus-associated lymphoid tissue in tolerant lung allografts promotes peripheral tolerance.
The Journal of clinical investigation 12, 2020 | Pubmed ID: 33196461
Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity.
Cell metabolism 02, 2021 | Pubmed ID: 33278339
Circulating mitochondrial DNA is an early indicator of severe illness and mortality from COVID-19.
JCI insight 02, 2021 | Pubmed ID: 33444289
COVID-19 vaccination in our transplant recipients: The time is now.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 03, 2021 | Pubmed ID: 33487534
Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection.
bioRxiv : the preprint server for biology Feb, 2021 | Pubmed ID: 33655244
Innate immunity in lung transplantation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 07, 2021 | Pubmed ID: 34020867
Selective Imaging of Lung Macrophages Using [C]PBR28-Based Positron Emission Tomography.
Molecular imaging and biology 12, 2021 | Pubmed ID: 34137002
Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection.
Science immunology 05, 2021 | Pubmed ID: 34446527
Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report.
American journal of respiratory cell and molecular biology 02, 2022 | Pubmed ID: 35103557
Targeting fatty acid β-oxidation impairs monocyte differentiation and prolongs heart allograft survival.
JCI insight 04, 2022 | Pubmed ID: 35239515
Role of tertiary lymphoid organs in the regulation of immune responses in the periphery.
Cellular and molecular life sciences : CMLS Jun, 2022 | Pubmed ID: 35689679
Maintenance of airway epithelium in acutely rejected orthotopic vascularized mouse lung transplants.
American journal of respiratory cell and molecular biology Dec, 2007 | Pubmed ID: 17717320
CD4+ T lymphocytes are not necessary for the acute rejection of vascularized mouse lung transplants.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2008 | Pubmed ID: 18354199
The feasibility of diaphragmatic transplantation as potential therapy for treatment of respiratory failure associated with Duchenne muscular dystrophy: acute canine model.
The Journal of thoracic and cardiovascular surgery Jun, 2008 | Pubmed ID: 18544399
Pathogenesis, management, and consequences of primary graft dysfunction.
Seminars in thoracic and cardiovascular surgery , 2008 | Pubmed ID: 18707651
Orthotopic vascularized right lung transplantation in the mouse.
The Journal of thoracic and cardiovascular surgery Jun, 2010 | Pubmed ID: 20219214
Two-photon microscopy in pulmonary research.
Seminars in immunopathology Sep, 2010 | Pubmed ID: 20589501
Polarized alloantigen presentation by airway epithelial cells contributes to direct CD8+ T cell activation in the airway.
American journal of respiratory cell and molecular biology Jun, 2011 | Pubmed ID: 21653906
Quantitative monitoring of mouse lung tumors by magnetic resonance imaging.
Nature protocols Jan, 2012 | Pubmed ID: 22222788
Current status of immunotherapy for the treatment of lung cancer.
Journal of thoracic disease Dec, 2010 | Pubmed ID: 22263052
Lung transplant acceptance is facilitated by early events in the graft and is associated with lymphoid neogenesis.
Mucosal immunology Sep, 2012 | Pubmed ID: 22549742
Central memory CD8+ T lymphocytes mediate lung allograft acceptance.
The Journal of clinical investigation Mar, 2014 | Pubmed ID: 24569377
The role of neutrophil myeloperoxidase in models of lung tumor development.
Cancers May, 2014 | Pubmed ID: 24821130
Imaging mouse lung allograft rejection with (1)H MRI.
Magnetic resonance in medicine May, 2015 | Pubmed ID: 24954886
Lung transplant immunosuppression - time for a new approach?
Expert review of clinical immunology Nov, 2014 | Pubmed ID: 25220652
DAP12 expression in lung macrophages mediates ischemia/reperfusion injury by promoting neutrophil extravasation.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2015 | Pubmed ID: 25762783
Selective targeting of IL-2 to NKG2D bearing cells for improved immunotherapy.
Nature communications Sep, 2016 | Pubmed ID: 27650575
Endotracheal tube-induced sore throat pain and inflammation is coupled to the release of mitochondrial DNA.
Molecular pain , 2017 | Pubmed ID: 28929859
Eosinophils promote inducible NOS-mediated lung allograft acceptance.
JCI insight Dec, 2017 | Pubmed ID: 29263310
Vendor-specific microbiome controls both acute and chronic murine lung allograft rejection by altering CD4 Foxp3 regulatory T cell levels.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Oct, 2019 | Pubmed ID: 31278849
Deciphering the role of eosinophils in solid organ transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Apr, 2020 | Pubmed ID: 31647606
Solving the Conundrum of Eosinophils in Alloimmunity.
Transplantation Aug, 2022 | Pubmed ID: 34966103
Necroptosis triggers spatially restricted neutrophil-mediated vascular damage during lung ischemia reperfusion injury.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2022 | Pubmed ID: 35238643
Short telomeres in lung transplantation: Known unknowns.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation May, 2022 | Pubmed ID: 35351386
Ischemia reperfusion injury facilitates lung allograft acceptance through IL-33-mediated activation of donor-derived IL-5 producing group 2 innate lymphoid cells.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Aug, 2022 | Pubmed ID: 35510760
Loss of stromal cell Thy-1 plays a critical role in lipopolysaccharide induced chronic lung allograft dysfunction.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation Aug, 2022 | Pubmed ID: 35691796
The role of neutrophil extracellular traps in acute lung injury.
Frontiers in immunology , 2022 | Pubmed ID: 35967320
Reprogramming alveolar macrophage responses to TGF-β reveals CCR2+ monocyte activity that promotes bronchiolitis obliterans syndrome.
The Journal of clinical investigation Oct, 2022 | Pubmed ID: 36189800
Avoid being trapped by your liver: ischemia-reperfusion injury in liver transplant triggers S1P-mediated NETosis.
The Journal of clinical investigation Feb, 2023 | Pubmed ID: 36719374
Increased clonal hematopoiesis involving DNA damage response genes in patients undergoing lung transplantation.
JCI insight Apr, 2023 | Pubmed ID: 36853803
Resolvin D1 prevents injurious neutrophil swarming in transplanted lungs.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2023 | Pubmed ID: 37487095
A Pilot Randomized Controlled Trial of De Novo Belatacept-based Immunosuppression After Lung Transplantation.
Transplantation Oct, 2023 | Pubmed ID: 37899481
Eosinophils restrain humoral alloimmunity after lung transplantation.
JCI insight Feb, 2024 | Pubmed ID: 38329123
Alveolar macrophage-CD8 T cell interactions after acute lung allograft dysfunction: Insights from single-cell RNA sequencing.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation Mar, 2024 | Pubmed ID: 38490571
Zhongcheng Mei1,
Mojtaba Taheri1,
Elizabeth A. Jacobsen2,
Wenjun Li3,4,
Andrew E. Gelman3,4,
Daniel Kreisel3,4,
Alexander Sasha Krupnick1,5
1Department of Surgery, University of Maryland Medical Center,
2Division of Allergy, Asthma and Clinical Immunology, Mayo Clinic,
3Department of Surgery, Washington University in St. Louis,
4Department of Pathology & Immunology, Washington University in St. Louis,
5Department of Microbiology and Immunology, University of Maryland Medical Center
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