Norbert Frey

Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress.

Alterations of tension-dependent ATP utilization in a transgenic rat model of hypertrophic cardiomyopathy.

Calsarcin-2 deficiency increases exercise capacity in mice through calcineurin/NFAT activation.

HBEGF, SRA1, and IK: Three cosegregating genes as determinants of cardiomyopathy.

Whole-genome analysis of gene expression associates the ubiquitin-proteasome system with the cardiomyopathy phenotype in disease-sensitized congenic mouse strains.

TREK-1 (K2.1) K channels are suppressed in patients with atrial fibrillation and heart failure and provide therapeutic targets for rhythm control.

Comprehensive plasma and tissue profiling reveals systemic metabolic alterations in cardiac hypertrophy and failure.

Catheter ablation of atrial fibrillation in women with heart failure with preserved ejection fraction.

AAV-mediated TIMP-1 overexpression in aortic tissue reduces the severity of allograft vasculopathy in mice.

AAV-mediated AP-1 decoy oligonucleotide expression inhibits aortic elastolysis in a mouse model of Marfan syndrome.

Epigenetic regulation of cardiac electrophysiology in atrial fibrillation: HDAC2 determines action potential duration and suppresses NRSF in cardiomyocytes.

Improvement of renal function after transcatheter aortic valve replacement and its impact on survival.

Alginate hydrogel polymers enable efficient delivery of a vascular-targeted AAV vector into aortic tissue.

Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease.

Impact of Anesthesia Strategy and Valve Type on Clinical Outcomes After Transcatheter Aortic Valve Replacement.

AAV-mediated expression of NFAT decoy oligonucleotides protects from cardiac hypertrophy and heart failure.

Safety and effectiveness of Phoenix atherectomy for endovascular treatment in calcified common femoral artery lesions.

Histone deacetylase 2-dependent ventricular electrical remodeling in a porcine model of early heart failure.

Basophils balance healing after myocardial infarction via IL-4/IL-13.

Newly acquired complete right bundle branch block early after heart transplantation is associated with lower survival.

High-sensitivity cardiac troponin T determines all-cause mortality in cancer patients: a single-centre cohort study.

PASCAL-based mitral valve repair in an all-comer population: acute and mid-term clinical results.

Atrial fibrillation before heart transplantation is a risk factor for post-transplant atrial fibrillation and mortality.

Influence of receptor selectivity on benefits from SGLT2 inhibitors in patients with heart failure: a systematic review and head-to-head comparative efficacy network meta-analysis.

Muscle-specific Cand2 is translationally upregulated by mTORC1 and promotes adverse cardiac remodeling.

Non-Vitamin K Antagonist Oral Anticoagulants in Coronary Artery Disease.

SH3-Binding Glutamic Acid Rich-Deficiency Augments Apoptosis in Neonatal Rat Cardiomyocytes.

Electrical Ventricular Remodeling in Dilated Cardiomyopathy.

Controlling my genome with my smartphone: first clinical experiences of the PROMISE system.

Diagnostic Work-Up of Cardiac Amyloidosis Using Cardiovascular Imaging: Current Standards and Practical Algorithms.

Transcatheter aortic valve implantation versus surgical aortic valve replacement in patients with severe aortic stenosis: a systematic review and meta-analysis.

Cancer-A Major Cardiac Comorbidity With Implications on Cardiovascular Metabolism.

HFA-PEFF score: prognosis in patients with preserved ejection fraction after transcatheter aortic valve implantation.

One-year results following PASCAL-based or MitraClip-based mitral valve transcatheter edge-to-edge repair.

MicroRNAs Regulate TASK-1 and Are Linked to Myocardial Dilatation in Atrial Fibrillation.

The predictive value of self-compassion for psychological adjustment in left ventricular assist device patients: an observational study.

SRF: a seriously responsible factor in cardiac development and disease.

VARS2 Depletion Leads to Activation of the Integrated Stress Response and Disruptions in Mitochondrial Fatty Acid Oxidation.

Case report of an S-ICD implantation for secondary prevention in a patient with complex congenital heart disease, dextrocardia, and situs solitus.

Adeno-Associated Virus-Mediated Gene Transfer of Inducible Nitric Oxide Synthase to an Animal Model of Pulmonary Hypertension.

Restoration of Cardiomyogenesis in Aged Mouse Hearts by Voluntary Exercise.

Impact of moderate or severe left ventricular outflow tract calcification on clinical outcomes of patients with severe aortic stenosis undergoing transcatheter aortic valve implantation with self- and balloon-expandable valves: a post hoc analysis from the SOLVE-TAVI trial.

Large Mobile Left Ventricular Thrombi Formation in a 32-Year-Old Despite Direct Oral Anticoagulation With Dabigatran.

Catheter Ablation of Atrial Fibrillation in Patients With Heart Failure and Preserved Ejection Fraction.

Long-Term Patency of Venous Conduits Targeting the Right Coronary Artery System-Single Is Superior to Sequential bypass Grafting.

Haemodynamic Effects of Sacubitril/Valsartan Initiation in Outpatients with Chronic Heart Failure.

The Obesity Paradox in Heart Failure: Is It Still Valid in Light of New Therapies?

Genotype Complements the Phenotype: Identification of the Pathogenicity of an LMNA Splice Variant by Nanopore Long-Read Sequencing in a Large DCM Family.

Blockade of Wnt Secretion Attenuates Myocardial Ischemia-Reperfusion Injury by Modulating the Inflammatory Response.

Verapamil inhibits Kir2.3 channels by binding to the pore and interfering with PIP binding.

Initial experience with transcatheter tricuspid valve repair in patients with cardiac amyloidosis.

Cardiac Troponins for the Clinical Management of Patients with Claudication and without Cardiac Symptoms.

Exploring biomarkers in routine diagnostics for the risk stratification of older patients in the Chest Pain Unit: a prospective cohort study.

Prognostic relevance of gradual weight changes on long-term mortality in chronic heart failure.

Coronary Computed Tomography vs. Cardiac Magnetic Resonance Imaging in the Evaluation of Coronary Artery Disease.

Dynamic Morphology of the Ascending Aorta and Its Implications for Proximal Landing in Thoracic Endovascular Aortic Repair.

Left atrial appendage closure in end-stage renal disease and hemodialysis: Data from a German multicenter registry.

Influence of Tricuspid Regurgitation After Heart Transplantation: A Single-center Experience.

The DZHK research platform: maximisation of scientific value by enabling access to health data and biological samples collected in cardiovascular clinical studies.

Adapted clustering method for generic analysis of histological fibrosis staining as an open source tool.

Mid-regional pro-adrenomedullin and lactate levels for risk stratification in patients with out-of-hospital cardiac arrest.

A distributable German clinical corpus containing cardiovascular clinical routine doctor's letters.

Safety, Effectiveness, and Midterm Results of Endovascular Treatment for the Common Femoral Artery: A Two Centre Atherectomy Trial.

Exploring the Involvement of Gut Microbiota in Cancer Therapy-Induced Cardiotoxicity.

Aspirin use and bleeding events during thrombocytopenia after autologous stem-cell transplantation for multiple myeloma.

Translational control of Ybx1 expression regulates cardiac function in response to pressure overload in vivo.

Effector T cell chemokine IP-10 predicts cardiac recovery and clinical outcomes post-myocardial infarction.

Prognosis of light chain amyloidosis: a multivariable analysis for survival prediction in patients with cardiac involvement proven by endomyocardial biopsy.

Long-Term Trajectories of Biomarkers, Functional, and Echocardiographic Parameters in Patients with Chronic Heart Failure from Dilated or Ischaemic Cardiomyopathy.

Glycaemic control and insulin therapy are significant confounders of the obesity paradox in patients with heart failure and diabetes mellitus.

Modification of the GRACE Risk Score for Risk Prediction in Patients With Acute Coronary Syndromes.

Pericoronary adipose tissue attenuation is associated with non-calcified plaque burden in patients with chronic coronary syndromes.

Activation of neurokinin-III receptors modulates human atrial TASK-1 currents.

Complications in patients with cardiogenic shock on veno-arterial extracorporeal membrane oxygenation therapy: distribution and relevance. Results from an international, multicentre cohort study.

Amino acid auxotrophies in human gut bacteria are linked to higher microbiome diversity and long-term stability.

Recurrent ventricular tachycardia originating from the "left ventricular summit" effectively eliminated by stereotactic irradiation - A case report.

GPD1L-A306del modifies sodium current in a family carrying the dysfunctional SCN5A-G1661R mutation associated with Brugada syndrome.

Multi-parametric non-contrast cardiac magnetic resonance for the differentiation between cardiac amyloidosis and hypertrophic cardiomyopathy.

Insulin resistance in Takotsubo syndrome.

Acute antiarrhythmic effects of SGLT2 inhibitors-dapagliflozin lowers the excitability of atrial cardiomyocytes.

Regnase-1 overexpression as a therapeutic approach of Marfan syndrome.

Acute changes in cardiac dimensions, function, and longitudinal mechanics in healthy individuals with and without high-altitude induced pulmonary hypertension at 4559 m.

Evaluation of all-cause mortality and cardiovascular safety in patients receiving chimeric antigen receptor T cell therapy: a prospective cohort study.

Reverse cardio-oncology: is heart failure-mediated gut dysbiosis the mechanistic driver of colorectal cancer progression?

Long-term safety and effectiveness of the Fantom bioresorbable coronary artery scaffold: final results of the FANTOM II trial.

Transcatheter or Surgical Treatment of Aortic-Valve Stenosis.

Design, Rationale and Initial Findings From HERA-FIB on 10 222 Patients With Atrial Fibrillation Presenting to an Emergency Department Over An 11-Year Period.

Prognostic Value of Standard Heart Failure Medication in Patients with Cardiac Transthyretin Amyloidosis.

A porcine large animal model of radiofrequency ablation-induced left bundle branch block.

Accelerated high sensitivity troponin diagnostics: ready for an even faster pace?

Editorial: Proteostasis in cardiac health and disease.

Electrophysiological Effects of the Sodium-Glucose Co-Transporter-2 (SGLT2) Inhibitor Dapagliflozin on Human Cardiac Potassium Channels.

Cardiac stereotactic body radiotherapy to treat malignant ventricular arrhythmias directly affects the cardiomyocyte electrophysiology.

Personalized care in dilated cardiomyopathy: Rationale and study design of the activeDCM trial.

Response to therapy with tafamidis 61 mg in patients with cardiac transthyretin amyloidosis: real-world experience since approval.

Virtual cardiovascular magnetic resonance training proves feasible and effective: survey data from international participants of the CMR Academy Berlin, Germany.

CITED4 gene therapy protects against maladaptive cardiac remodeling after ischemia/reperfusion injury in mice.

Effects of high- versus low-intensity lipid-lowering treatment in patients undergoing serial coronary computed tomography angiography: results of the multi-center LOCATE study.

Community-based analysis of stroke prevention and effect of public interventions in atrial fibrillation: results from the ARENA project.

Favorable safety profile of NOAC therapy in patients after tricuspid transcatheter edge-to-edge repair.

Calcineurin signaling promotes takotsubo syndrome.

Transient Inhibition of Translation Improves Cardiac Function After Ischemia/Reperfusion by Attenuating the Inflammatory Response.

Natriuretic peptides and cardiac hs-troponins as surrogates of cardiomyocyte stress: clinical value in hypertrophic cardiomyopathy?

EASIX (endothelial activation and stress index) predicts mortality in patients with coronary artery disease.

Risk Stratification in Nonischemic Dilated Cardiomyopathy Using CMR Imaging: A Systematic Review and Meta-Analysis.

A systematic framework for understanding the microbiome in human health and disease: from basic principles to clinical translation.

Circulating extracellular vesicles as biomarkers in the diagnosis, prognosis and therapy of cardiovascular diseases.

2 Rare Syndromes in 1 Patient: Determining the Cause of Sudden Cardiac Arrest.

A Remote Patient Monitoring System With Feedback Mechanisms Using a Smartwatch: Concept, Implementation, and Evaluation Based on the activeDCM Randomized Controlled Trial.

Cardiovascular Events After Chimeric Antigen Receptor T-Cell Therapy for Advanced Hematologic Malignant Neoplasms: A Meta-Analysis.

Endothelial activation and stress index (EASIX) in coronary artery disease: a simplified measure as a promising biomarker.

Cardiac arrhythmias during and after thoracic irradiation for malignancies.

Optical control of cardiac electrophysiology by the photochromic ligand azobupivacaine 2.

Absence of cardiac impairment in patients after severe acute respiratory syndrome coronavirus type 2 infection: A long-term follow-up study.

Rationale and Design of the HERZCHECK trial: Detection of Early Heart Failure Using Telemedicine and CMR in Structurally Weak Regions (NCT05122793).

Composite cardiac computed tomography angiography score for improved risk assessment in chronic coronary syndromes.

A novel uORF regulates folliculin to promote cell growth and lysosomal biogenesis during cardiac stress.

Clinical impact of inappropriate DOAC dosing in atrial fibrillation: Insights from a real-world registry.