Douglas Mental Health University Institute,
Department of Psychiatry,
Department of Neurology and Neurosurgery,
Faculty of Medicine,
Ludmer Centre for Neuroinformatics & Mental Health,
Department of Neurology and Neurosurgery, Faculty of Medicine
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Chronic phencyclidine treatment increases dendritic spine density in prefrontal cortex and nucleus accumbens neurons.
Synapse (New York, N.Y.) Dec, 2007 | Pubmed ID: 17879264
Netrin-1 receptor-deficient mice show enhanced mesocortical dopamine transmission and blunted behavioural responses to amphetamine.
The European journal of neuroscience Dec, 2007 | Pubmed ID: 18005074
Altered netrin-1 receptor expression in dopamine terminal regions following neonatal ventral hippocampal lesions in the rat.
Synapse (New York, N.Y.) Jan, 2009 | Pubmed ID: 18932228
The 31st annual meeting of the Canadian College of Neuropsychopharmacology: Toronto, Ontario, June 6-9, 2008.
Journal of psychiatry & neuroscience : JPN Jan, 2009 | Pubmed ID: 19125215
Alcohol dependence-related increase of glial cell density in the anterior cingulate cortex of suicide completers.
Journal of psychiatry & neuroscience : JPN Jul, 2009 | Pubmed ID: 19568479
Post-pubertal emergence of a dopamine phenotype in netrin-1 receptor-deficient mice.
The European journal of neuroscience Oct, 2009 | Pubmed ID: 19788579
Netrin-1 receptor in the ventral tegmental area is required for sensitization to amphetamine.
The European journal of neuroscience Apr, 2010 | Pubmed ID: 20345916
Prenatal inflammation-induced hypoferremia alters dopamine function in the adult offspring in rat: relevance for schizophrenia.
PloS one Jun, 2010 | Pubmed ID: 20532043
Peri-pubertal emergence of UNC-5 homologue expression by dopamine neurons in rodents.
PloS one Jul, 2010 | Pubmed ID: 20628609
Role of netrin-1 in the organization and function of the mesocorticolimbic dopamine system.
Journal of psychiatry & neuroscience : JPN Sep, 2011 | Pubmed ID: 21481303
Abolition of the behavioral phenotype of adult netrin-1 receptor deficient mice by exposure to amphetamine during the juvenile period.
Psychopharmacology Oct, 2011 | Pubmed ID: 21523346
The netrin receptor DCC is required in the pubertal organization of mesocortical dopamine circuitry.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jun, 2011 | Pubmed ID: 21653843
Leptin and interleukin-6 alter the function of mesolimbic dopamine neurons in a rodent model of prenatal inflammation.
Psychoneuroendocrinology Jul, 2012 | Pubmed ID: 22133515
Juvenile exposure to methylphenidate reduces cocaine reward and alters netrin-1 receptor expression in adulthood.
Behavioural brain research Apr, 2012 | Pubmed ID: 22249134
Association between schizophrenia and genetic variation in DCC: a case-control study.
Schizophrenia research May, 2012 | Pubmed ID: 22418395
Adolescence: a time of transition for the phenotype of dcc heterozygous mice.
Psychopharmacology Apr, 2014 | Pubmed ID: 23572211
unc5c haploinsufficient phenotype: striking similarities with the dcc haploinsufficiency model.
The European journal of neuroscience Sep, 2013 | Pubmed ID: 23738838
Haloperidol treatment downregulates DCC expression in the ventral tegmental area.
Neuroscience letters Jul, 2014 | Pubmed ID: 24861518
The Netrin-1 receptor DCC is a regulator of maladaptive responses to chronic morphine administration.
BMC genomics May, 2014 | Pubmed ID: 24884839
Amphetamine in adolescence disrupts the development of medial prefrontal cortex dopamine connectivity in a DCC-dependent manner.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Mar, 2015 | Pubmed ID: 25336209
dcc Haploinsufficiency results in blunted sensitivity to cocaine enhancement of reward seeking.
Behavioural brain research Feb, 2016 | Pubmed ID: 26005129
Resilience to amphetamine in mouse models of netrin-1 haploinsufficiency: role of mesocortical dopamine.
Psychopharmacology Oct, 2015 | Pubmed ID: 26264903
Mesocortical Dopamine Phenotypes in Mice Lacking the Sonic Hedgehog Receptor Cdon.
eNeuro , 2016 | Pubmed ID: 27419218
DCC Confers Susceptibility to Depression-like Behaviors in Humans and Mice and Is Regulated by miR-218.
Biological psychiatry Feb, 2017 | Pubmed ID: 27773352
Dcc haploinsufficiency regulates dopamine receptor expression across postnatal lifespan.
Neuroscience Mar, 2017 | Pubmed ID: 28108253
A non-invasive restraining system for awake mouse imaging.
Journal of neuroscience methods Aug, 2017 | Pubmed ID: 28634149
DCC Receptors Drive Prefrontal Cortex Maturation by Determining Dopamine Axon Targeting in Adolescence.
Biological psychiatry Jan, 2018 | Pubmed ID: 28720317
Making Dopamine Connections in Adolescence.
Trends in neurosciences Dec, 2017 | Pubmed ID: 29032842
Adolescence and Reward: Making Sense of Neural and Behavioral Changes Amid the Chaos.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2017 | Pubmed ID: 29118215
Non-Contingent Exposure to Amphetamine in Adolescence Recruits miR-218 to Regulate Dcc Expression in the VTA.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Mar, 2018 | Pubmed ID: 29154364
An optimized immunohistochemistry protocol for detecting the guidance cue Netrin-1 in neural tissue.
MethodsX , 2018 | Pubmed ID: 29276694
Dopamine Development in the Mouse Orbital Prefrontal Cortex Is Protracted and Sensitive to Amphetamine in Adolescence.
eNeuro , 2018 | Pubmed ID: 29333488
Mesocorticolimbic Connectivity and Volumetric Alterations in Mutation Carriers.
The Journal of neuroscience : the official journal of the Society for Neuroscience 05, 2018 | Pubmed ID: 29712788
Guidance cues: linking drug use in adolescence with psychiatric disorders.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Jan, 2019 | Pubmed ID: 30275561
Early Adolescence is a Critical Period for the Maturation of Inhibitory Behavior.
Cerebral cortex (New York, N.Y. : 1991) Aug, 2019 | Pubmed ID: 30295713
Neural function in DCC mutation carriers with and without mirror movements.
Annals of neurology 03, 2019 | Pubmed ID: 30666715
MiR-218: a molecular switch and potential biomarker of susceptibility to stress.
Molecular psychiatry May, 2020 | Pubmed ID: 30980043
DCC-related developmental effects of abused- versus therapeutic-like amphetamine doses in adolescence.
Addiction biology Jul, 2020 | Pubmed ID: 31192517
The Netrin-1/DCC guidance system: dopamine pathway maturation and psychiatric disorders emerging in adolescence.
Molecular psychiatry Feb, 2020 | Pubmed ID: 31659271
Low-cost conditioned place preference setup including video recording and analysis of behaviour.
MethodsX , 2020 | Pubmed ID: 32405466
The Netrin-1/DCC Guidance Cue Pathway as a Molecular Target in Depression: Translational Evidence.
Biological psychiatry Oct, 2020 | Pubmed ID: 32593422
Dopamine Axon Targeting in the Nucleus Accumbens in Adolescence Requires Netrin-1.
Frontiers in cell and developmental biology , 2020 | Pubmed ID: 32714924
gene network in the prefrontal cortex is associated with total brain volume in childhood.
Journal of psychiatry & neuroscience : JPN Nov, 2020 | Pubmed ID: 33206040
miR-218 in Adolescence Predicts and Mediates Vulnerability to Stress.
Biological psychiatry May, 2021 | Pubmed ID: 33384174
Unique effects of social defeat stress in adolescent male mice on the Netrin-1/DCC pathway, prefrontal cortex dopamine and cognition (Social stress in adolescent vs. adult male mice).
eNeuro Feb, 2021 | Pubmed ID: 33619036
MicroRNA regulation of prefrontal cortex development and psychiatric risk in adolescence.
Seminars in cell & developmental biology Oct, 2021 | Pubmed ID: 33933350
MicroRNAs as promising peripheral sensors of prefrontal cortex developmental trajectory and psychiatric risk.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Jan, 2022 | Pubmed ID: 34312494
Mechanisms of cortical development: From the embryo to adulthood.
Seminars in cell & developmental biology Oct, 2021 | Pubmed ID: 34462250
Mesocorticolimbic Dopamine Pathways Across Adolescence: Diversity in Development.
Frontiers in neural circuits , 2021 | Pubmed ID: 34566584
Custom-Built Operant Conditioning Setup for Calcium Imaging and Cognitive Testing in Freely Moving Mice.
eNeuro , 2022 | Pubmed ID: 35105659
Corticolimbic DCC gene co-expression networks as predictors of impulsivity in children.
Molecular psychiatry Jun, 2022 | Pubmed ID: 35388180
Reduced dopamine release in Dcc haploinsufficiency male mice abolishes the rewarding effects of cocaine but not those of morphine and ethanol.
Psychopharmacology Mar, 2023 | Pubmed ID: 36471064
We're not in Kansas anymore: ectopic dopaminergic terminals as an explanation for the positive symptoms in psychiatric pathology.
Journal of psychiatry & neuroscience : JPN , 2023 | Pubmed ID: 36810305
Awakening the dormant: Role of axonal guidance cues in stress-induced reorganization of the adult prefrontal cortex leading to depression-like behavior.
Frontiers in neural circuits , 2023 | Pubmed ID: 37035502
Gains and Losses: Resilience to Social Defeat Stress in Adolescent Female Mice.
Biological psychiatry Jan, 2024 | Pubmed ID: 37355003
Amphetamine disrupts dopamine axon growth in adolescence by a sex-specific mechanism in mice.
Nature communications Jul, 2023 | Pubmed ID: 37419977
Relationship between insulin and Netrin-1/DCC guidance cue pathway regulation in the prefrontal cortex of rodents exposed to prenatal dietary restriction.
Journal of developmental origins of health and disease Aug, 2023 | Pubmed ID: 37431265
Novel Functional Genomics Approaches Bridging Neuroscience and Psychiatry.
Biological psychiatry global open science Jul, 2023 | Pubmed ID: 37519472
Axo-glial interactions between midbrain dopamine neurons and oligodendrocyte lineage cells in the anterior corpus callosum.
Brain structure & function Nov, 2023 | Pubmed ID: 37668732
Preparation and processing of dried blood spots for microRNA sequencing.
Biology methods & protocols , 2023 | Pubmed ID: 37901452
RGMa and Neogenin control dendritic spine morphogenesis via WAVE Regulatory Complex-mediated actin remodeling.
Frontiers in molecular neuroscience , 2023 | Pubmed ID: 37928069
Rewiring the future: drugs abused in adolescence may predispose to mental illness in adult life by altering dopamine axon growth.
Journal of neural transmission (Vienna, Austria : 1996) Dec, 2023 | Pubmed ID: 38036858
Andrea Harée Pantoja-Urbán1,
Samuel Richer1,
Michel Giroux2,
Dominique Nouel2,
Cecilia Flores2,3,4,5
1Integrated Program in Neuroscience, McGill University,
2Douglas Mental Health University Institute, McGill University,
3Department of Psychiatry, McGill University,
4Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University,
5Ludmer Centre for Neuroinformatics & Mental Health, McGill University
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