School of Biochemistry
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Generation of Escherichia coli nitroreductase mutants conferring improved cell sensitization to the prodrug CB1954.
Cancer research Sep, 2003 | Pubmed ID: 14500391
Nitroaryl phosphoramides as novel prodrugs for E. coli nitroreductase activation in enzyme prodrug therapy.
Journal of medicinal chemistry Nov, 2003 | Pubmed ID: 14584930
Nitroreductase: a prodrug-activating enzyme for cancer gene therapy.
Clinical and experimental pharmacology & physiology Nov, 2004 | Pubmed ID: 15566399
Structural and mechanistic studies of Escherichia coli nitroreductase with the antibiotic nitrofurazone. Reversed binding orientations in different redox states of the enzyme.
The Journal of biological chemistry Apr, 2005 | Pubmed ID: 15684426
Crystal structure of SmcL, a bacterial neutral sphingomyelinase C from Listeria.
The Journal of biological chemistry Oct, 2005 | Pubmed ID: 16093240
Insertion of the enteropathogenic Escherichia coli Tir virulence protein into membranes in vitro.
The Journal of biological chemistry Mar, 2006 | Pubmed ID: 16436373
Kinetic and structural characterisation of Escherichia coli nitroreductase mutants showing improved efficacy for the prodrug substrate CB1954.
Journal of molecular biology Apr, 2007 | Pubmed ID: 17350040
Conformation of the EPEC Tir protein in solution: investigating the impact of serine phosphorylation at positions 434/463.
Biophysical journal Jul, 2007 | Pubmed ID: 17449672
Molecular architecture of the "stressosome," a signal integration and transduction hub.
Science (New York, N.Y.) Oct, 2008 | Pubmed ID: 18832644
Crystal structure of Streptococcus pyogenes sortase A: implications for sortase mechanism.
The Journal of biological chemistry Mar, 2009 | Pubmed ID: 19129180
Solution structure of the major (Spy0128) and minor (Spy0125 and Spy0130) pili subunits from Streptococcus pyogenes.
European biophysics journal : EBJ Feb, 2010 | Pubmed ID: 19290517
Crystal structures of Cif from bacterial pathogens Photorhabdus luminescens and Burkholderia pseudomallei.
PloS one , 2009 | Pubmed ID: 19440549
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