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Fairfield University

6 ARTICLES PUBLISHED IN JoVE

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Behavior

Automated, Quantitative Cognitive/Behavioral Screening of Mice: For Genetics, Pharmacology, Animal Cognition and Undergraduate Instruction
C. R. Gallistel 1, Fuat Balci 1,2, David Freestone 1,3, Aaron Kheifets 1, Adam King 4
1Department of Psychology, Rutgers University, 2Department of Psychology, Koç University, 3Center for Neural Science, New York University, 4Department of Mathematics & Computer Science, Fairfield University

Fully automated system for measuring physiologically meaningful properties of the mechanisms mediating spatial localization, temporal localization, duration, rate and probability estimation, risk assessment, impulsivity, and the accuracy and precision of memory, in order to assess the effects of genetic and pharmacological manipulations on foundational mechanisms of cognition in mice.

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Bioengineering

Encapsulating Cytochrome c in Silica Aerogel Nanoarchitectures without Metal Nanoparticles while Retaining Gas-phase Bioactivity
Amanda S. Harper-Leatherman 1, Elizabeth R. Pacer 1, Nina D. Kosciuszek 1
1Department of Chemistry & Biochemistry, Fairfield University

This procedure describes how to encapsulate cytochrome c (cyt. c) in silica (SiO2) sol-gels, process these gels to form bioaerogels, and use these bioaerogels to rapidly recognize nitric oxide (NO) through a gas-phase reaction. This type of protocol may aid in the future development of biosensors or other bioanalytical devices.

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Chemistry

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides
Ruben Neves 1, Kailyn Stephens 1, Jillian E. Smith-Carpenter 1
1Department of Chemistry and Biochemistry, Fairfield University

A protocol for the synthesis of a 1,2-dithiolane modified peptide and the characterization of the supramolecular structures resulting from the peptide self-assembly.

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Education

Preparation of SNS Cobalt(II) Pincer Model Complexes of Liver Alcohol Dehydrogenase
John R. Miecznikowski 1, Jerry P. Jasinski 2, Manpreet Kaur 2, Sheila C. Bonitatibus 1, Emilse M. Almanza 1, Rami M. Kharbouch 1, Samantha E. Zygmont 1, Kendra R. Landy 1
1Department of Chemistry and Biochemistry, Fairfield University, 2Department of Chemistry, Keene State College

The preparation of SNS pincer cobalt(II) model complexes of liver alcohol dehydrogenase is presented here. The complexes can be prepared by reacting the ligand precursor with CoCl2·6H2O and can then be recrystallized by allowing diethyl ether to slowly diffuse into an acetonitrile solution that contains the cobalt complex.

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Chemistry

An Inexpensive Adaptation of a Commercial Microwave Reactor for Solid Phase Peptide Synthesis
Matthew A. Kubasik 1, Sarah E. Breslow 1, Kelley G. Ross 1, Madelyn E. Coogan 1, Colin M. Gorman 1
1Department of Chemistry & Biochemistry, Fairfield University

A simple, inexpensive, and novel apparatus for performing solid phase peptide syntheses in a commercial microwave reactor is presented.

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Neuroscience

Restraint to Induce Stress in Mice and Rats
Karl T. Schmidt 1
1Department of Psychological and Brain Sciences, Fairfield University

This article covers the procedures to induce stress responses using physical restraint stress in mice and rats. Additional considerations that should be observed when selecting and using restraint stress in rodent models are discussed.

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