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CHU Nantes

3 ARTICLES PUBLISHED IN JoVE

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Medicine

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice
Audrey Ayer 1, Frederic Borel 1, Francois Moreau 1, Xavier Prieur 1, Michel Neunlist 2, Bertrand Cariou 3, Claire Blanchard *1,4, Cedric Le May *1
1l'Institut du Thorax, INSERM, CNRS, UNIV Nantes, 2CHU Nantes, Institut des Maladies de l'Appareil Digestif, INSERM U913, 3l'Institut du Thorax, INSERM, CNRS, UNIV Nantes, CHU Nantes, 4Service de Clinique Chirurgicale Digestive et Endocrinienne, CHU de Nantes

Bariatric surgery is the most efficient way to reduce body weight and the deadly metabolic complications (diabetes, obesity, and dyslipidemia) frequently associated with morbid obesity. Mouse models of bariatric surgery represent a unique asset for deciphering molecular mechanisms behind the beneficial effects of these surgeries on diabetes, hypertension, and dyslipidemia.

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Immunology and Infection

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Séverine Bézie 1,2, Claire Usal 1,2, Carole Guillonneau 1,2
1Centre de Recherche en Transplantation et Immunologie UMR 1064, INSERM, Université de Nantes, 2Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes

Here, we present a protocol to induce tolerance in transplantation, and assess in vitro and in vivo the suppressive capacity of distinct cell subsets from the recipient and the immune status of the recipient toward donor or exogenous antigens.

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Medicine

Single-Anastomosis Duodeno-Ileal Bypass with Sleeve Gastrectomy Model in Mice
Samuel Frey 1,2, Audrey Ayer 1, Thibaud Sotin 1, Victoria Lorant 1, Bertrand Cariou 1, Claire Blanchard *1,2, Cédric Le May *1
1CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes Université, 2Chirurgie Cancérologique, Digestive et Endocrinienne, Institut des Maladies de l'Appareil Digestif, Hôtel Dieu, CHU Nantes

Single-anastomosis duodeno-ileal bypass (SADI-S) is an emerging bariatric procedure with important metabolic effects. In this article, we present a reliable and reproducible model of SADI-S in mice.

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