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Mayo Clinic College of Medicine, Center for Individualized Medicine
2 ARTICLES PUBLISHED IN JoVE
JoVE Journal
Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis
Choong Yong Ung 1, Feng Guo 2, Xiaoling Zhang 3, Zhihui Zhu 3, Shizhen Zhu 1,3
1Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic College of Medicine, Center for Individualized Medicine, 2Tufts University School of Medicine, 3Department of Biochemistry and Molecular Biology, Mayo Clinic
The goal of this study is to demonstrate how the mosaic transgenesis strategy can be used in zebrafish to rapidly and efficiently assess the relative contributions of multiple oncogenes in tumor initiation and progression in vivo.
Cancer Research
Zebrafish Model of Neuroblastoma Metastasis
Zuag Paj Her 1, Kok Siong Yeo 1, Cassie Howe 1, Taylor Levee 1, Shizhen Zhu 1
1Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Mayo Clinic Cancer Center
This paper introduces the method of developing, characterizing, and tracking in real-time the tumor metastasis in zebrafish model of neuroblastoma, specifically in the transgenic zebrafish line with overexpression of MYCN and LMO1, which develops metastasis spontaneously.
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