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LMU München

2 ARTICLES PUBLISHED IN JoVE

Neuroscience

A Visual Guide to Sorting Electrophysiological Recordings Using 'SpikeSorter'

Nicholas V. Swindale¹, Catalin Mitelut¹, Timothy H. Murphy², Martin A. Spacek^1,3

¹Ophthalmology and Visual Sciences, University of British Columbia, ²Department of Psychiatry, University of British Columbia, ³Neurobiology, Biology II, LMU München

The article shows how to use the program SpikeSorter to detect and sort spikes in extracellular recordings made with multi-electrode arrays.

Bioengineering

Metabolic Glycoengineering of Sialic Acid Using N-acyl-modified Mannosamines

Paul R. Wratil^1,2, Rüdiger Horstkorte³

¹Max von Pettenkofer-Institut & Genzentrum, Virologie, Nationales Referenzzentrum für Retroviren, Medizinische Fakultät, LMU München, ²Institut für Laboratoriumsmedizin, klinische Chemie und Pathobiochemie, Charité - Universitätsmedizin Berlin, ³Institut für Physiologische Chemie, Martin-Luther-Universität Halle-Wittenberg

Sialic acid is a typical monosaccharide-unit found in glycoconjugates. It is involved in a plethora of molecular and cellular interactions. Here we present a method to modify cell surface sialic acid expression using metabolic glycoengineering with N-acetylmannosamine derivatives.