Kinetic Screening of Nuclease Activity using Nucleic Acid ProbesAlien Balian *1,2,3, Javier Garcia Gonzalez *1,2,3, Nora Bastida 1,3, Khadija-Tul Kubra Akhtar 1,3, Baris A. Borsa 1,2,3, Frank J. Hernandez 1,2,3
1Department of Physics, Chemistry and Biology, Linköping University, 2Wallenberg Centre for Molecular Medicine (WCMM), 3Nucleic Acids Technologies Laboratory (NAT-lab), Linköping University
Altered nuclease activity has been associated with different human conditions, underlying its potential as a biomarker. The modular and easy to implement screening methodology presented in this paper allows the selection of specific nucleic acid probes for harnessing nuclease activity as a biomarker of disease.
