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Key Laboratory of Pathogenesis Mechanism and Control of Inflammatory-Autoimmune Diseases in Hebei Province

3 ARTICLES PUBLISHED IN JoVE

Medicine

Controlled Cortical Impact Model for Traumatic Brain Injury

Jennifer Romine¹, Xiang Gao¹, Jinhui Chen¹

¹Spinal Cord and Brain Injury Research Group, Stark Neuroscience Research Institute, Department of Neurological Surgery, Indiana University School of Medicine

Traumatic brain injuries (TBIs) remain a serious health problem. Using the controlled cortical impact surgery model, research on the effects of TBI and possible treatment methods may be performed.

Behavior

A Dual Task Procedure Combined with Rapid Serial Visual Presentation to Test Attentional Blink for Nontargets

Zhengang Lu^*1, Jessica Goold^*1, Ming Meng¹

¹Department of Psychological and Brain Sciences, Dartmouth College

This paper describes a novel dual task procedure combined with Rapid Serial Visual Presentation to look at attentional blink at varied stimulus onset asynchronies. This experimental procedure differed from others in that it tested attentional blink for nontargets.

Immunology and Infection

Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase (G6PI)-Induced RA Mice

Ming Meng^*1,2, Shengde Chen^*1,2, Xiang Gao^*1,2, Huifang Liu^*1,2, Yuanyuan Wang^*1,2, Jingnan Zhang^*1,2, Haiyang Dou^*1,2, Wenjuan Li^*1,2, Dongzhi Chen^*1,2

¹Medical School of Hebei University, ²Key Laboratory of Pathogenesis Mechanism and Control of Inflammatory-Autoimmune Diseases in Hebei Province

This protocol uses G6PI mixed peptides to construct rheumatoid arthritis models that are closer to that of human rheumatoid arthritis in CD4⁺ T cells and cytokines. High purity invariant natural killer T cells (mainly iNKT2) with specific phenotypes and functions were obtained by in vivo induction and in vitro purification for adoptive immunotherapy.