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Nagoya University Institute for Advanced Research

2 ARTICLES PUBLISHED IN JoVE

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Bioengineering

Selective Cell Elimination from Mixed 3D Culture Using a Near Infrared Photoimmunotherapy Technique
Kazuhide Sato 1, Peter L. Choyke 1, Kobayashi Hisataka 1
1Molecular Imaging Program, National Cancer Institute

Eliminating specific cells without damaging other cells is extremely difficult, especially in established tissue, yet there is an urgent need for a cell elimination method in the tissue engineering field. Here, we present a method for specific cell elimination from a mixed 3D cell culture using near infrared photoimmunotherapy (NIR-PIT).

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Medicine

Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination
Hirotoshi Yasui 1, Yuko Nishinaga 1, Shunichi Taki 1, Kazuomi Takahashi 1, Yoshitaka Isobe 1, Kazuhide Sato 1,2,3
1Respiratory Medicine, Nagoya University Graduate School of Medicine, 2Nagoya University Institute for Advanced Research, 3B3-Unit, Advanced Analytical and Diagnostic Imaging Center (AADIC)/Medical Engineering Unit (MEU), Nagoya University Institute for Advanced Research

Near-infrared photoimmunotherapy (NIR-PIT) is an emerging cancer therapeutic strategy that utilizes an antibody-photoabsorber (IR700Dye) conjugate and NIR light to destroy cancer cells. Here, we present a method to evaluate the antitumor effect of NIR-PIT in a mouse model of pleural disseminated lung cancer and malignant pleural mesothelioma using bioluminescence imaging.

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