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Mines Saint-Etienne

4 ARTICLES PUBLISHED IN JoVE

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Bioengineering

A Simple and Scalable Fabrication Method for Organic Electronic Devices on Textiles
Usein Ismailov 1, Esma Ismailova 1, Seiichi Takamatsu 2
1Department of Bioelectronics, Ecole Nationale Supérieure des Mines de Saint-Étienne, CMP-EMSE, MOC, 2Graduate School of Frontier Sciences, The University of Tokyo

In this paper, we present a protocol to selectively deposit organic materials on textiles, which allows for the direct integration of organic electronic devices with wearables. The fabricated devices can be fully integrated in textiles, respecting their mechanical appearance and enabling sensing capabilities.

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JoVE Core

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
Andrea Slezia *1,5, Christopher M. Proctor *2,3, Attila Kaszas 1,4, George G. Malliaras 2,3, Adam Williamson 1,5
1Aix Marseille Université, Institut de Neurosciences des Systèmes (INS), 2Electrical Engineering Division, University of Cambridge, 3Department of Bioelectronics, Centre Microélectronique de Provence - Ecole Nationale Supérieure des Mines de Saint-Étienne (CMP-EMSE), 4Institut de Neurosciences de la Timone, Centre National de la Recherche Scientifique (CNRS) UMR 7289 & Aix- Marseille Université, 5Neuroengineering Research Group, Interdisciplinary Excellence Center, Department of Medical Microbiology and Immunobiology, University of Szeged

The challenge of epilepsy research is to develop novel treatments for patients where classical therapy is inadequate. Using a new protocol—with the help of an implantable drug delivery system—we are able to control seizures in anesthetized mice by the electrophoretic delivery of GABA into the epileptic focus.

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Bioengineering

Conformable Wearable Electrodes: From Fabrication to Electrophysiological Assessment
Marina Galliani 1, Laura M. Ferrari 2, Esma Ismailova 1
1Centre CMP, Département BEL, Mines Saint-Etienne, 2INRIA, Université Côte d'Azur

Two recent technologies-tattoo and textiles-have demonstrated promising results in cutaneous sensing. Here, we present the fabrication and evaluation methods of tattoo and textile electrodes for cutaneous electrophysiological sensing. These electronic interfaces made of conductive polymers outperform the existing standards in terms of comfort and sensitivity.

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Cancer Research

Flexible Organic Electronic Devices for Pulsed Electric Field Therapy of Glioblastoma
Marie C. Lefevre 1, Attila Kaszas 1, Gerwin Dijk 1,2, Martin Baca 1, Olivier Baudino 2, Bastien Marchiori 2, Loig Kergoat 2, David Moreau 1, Franck Debarbieux 3,4,5, Rodney P. O'Connor 1
1Centre CMP, Bioelectronics Department, Mines Saint-Etienne, 2Panaxium SAS, 3Institut Universitaire de France, 4Institut des Neurosciences de la Timone (UMR7289), CNRS, Aix-Marseille Université, 5Centre Européen de Recherche en Imagerie Médicale, Aix-Marseille Université

This work describes the development of flexible interdigitated electrodes for implementation in 3D brain tumor models, namely, in vitro culture, in ovo model, and in vivo murine model. The proposed method can be used to evaluate the effects of pulsed electric fields on tumors at different levels of complexity.

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