Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention

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13.5K Views

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08:49 min

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October 16th, 2013

DOI :

10.3791/51079-v

October 16th, 2013

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Hilary S. McCarren¹^,²^,⁴, Jason T. Moore¹^,³^,⁴, Max B. Kelz¹^,²^,³^,⁴

¹Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, ²Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, ³Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, ⁴Center for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania

Podsumowanie

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Keywords General Anesthesia

Hypnosis

Loss Of Righting Reflex LORR

Return Of Righting Reflex RORR

Anesthetic Sensitivity

EC50

Hill Slope

Controlled Environmental Chambers

Inhaled Drug Delivery

Toxicology Studies

Vital Signs Monitoring

Rozdziały w tym wideo

0:05

Title

1:13

Test Apparatus Set-up

2:55

System Checking and Calibration

3:50

Temperature Transponder Implantation

4:22

Animal Habituation

5:02

Step-wise Testing os Anesthetic Sensitivity

6:35

Time to Emergence Testing

7:37

Results: Effect of Ibotenic Acid on Anesthetic Sensitivity

8:26

Conclusion

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