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JoVE Journal

Medicine

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Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention

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08:49 min

October 16th, 2013

October 16th, 2013

13,426 Views

0:05

Title

1:13

Test Apparatus Set-up

2:55

System Checking and Calibration

3:50

Temperature Transponder Implantation

4:22

Animal Habituation

5:02

Step-wise Testing os Anesthetic Sensitivity

6:35

Time to Emergence Testing

7:37

Results: Effect of Ibotenic Acid on Anesthetic Sensitivity

8:26

Conclusion

Loss of the righting reflex has long served as a standard behavioral surrogate for unconsciousness, also called hypnosis, in laboratory animals. Alterations in volatile anesthetic sensitivity caused by pharmacological interventions can be detected with a carefully controlled high-throughput assessment system, which may be adapted for delivery of any inhaled therapeutic.

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