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Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors

6.1K Views

08:45 min

July 17th, 2020

DOI :

10.3791/61457-v

July 17th, 2020


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SHP2

Rozdziały w tym wideo

0:04

Introduction

1:04

Transfection of HEK293T Cells

2:36

Incubation of Cells with SHP2 Inhibitors

5:11

Isothermal or Thermal Profile Gradient Heat Pulse

6:01

Results: Cellular Target Engagement of Allosteric SHP2 Inhibitors with SHP2-WT and SHP2-E76K Proteins

8:03

Conclusion

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