Transplantation of Human Stem Cell-Derived GABAergic Neurons into the Early Postnatal Mouse Hippocampus to Mitigate Neurodevelopmental Disorders

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2.3K Views

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05:00 min

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November 11th, 2022

DOI :

10.3791/64272-v

November 11th, 2022

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Ana Gonzalez-Ramos², Kerstin Laurin¹, Fredrik Berglind¹, Marco Ledri³, Merab Kokaia², My Andersson¹

¹Cellular Neurophysiology and Epilepsy Group, Epilepsy Centre, Department of Clinical Sciences, Lund University Hospital, ²Experimental Epilepsy Group, Epilepsy Centre, Department of Clinical Sciences, Lund University Hospital, ³Molecular Neurophysiology and Epilepsy Group, Epilepsy Center, Department of Clinical Sciences, Lund University Hospital

Podsumowanie

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Human Stem Cells

GABAergic Neurons

Transplantation

Neurodevelopmental Disorders

Cell Therapy

Interneuron Precursors

Hippocampus

Cell Detachment Solution

Single cell Suspension

Developmental Disorders

Rozdziały w tym wideo

0:04

Introduction

0:50

Preparation of the Single-Cell Suspension for Transplantation

2:09

Intrahippocampal Cell Transplantation

3:24

Results: hdINs into the Hippocampus of Newborn WT Mice and Cntnap2 KO Mice

4:20

Conclusion

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