Murine Hind Limb Explant Model for Studying the Mechanobiology of Achilles Tendon Impingement

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08:19 min

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December 8th, 2023

DOI :

10.3791/65801-v

December 8th, 2023

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Brian C. Wise¹^,², Keshia E. Mora¹^,², Whasil Lee¹^,²^,³, Mark R. Buckley¹^,²

¹Department of Biomedical Engineering, University of Rochester, ²Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, ³Department of Pharmacology and Physiology, University of Rochester Medical Center

Podsumowanie

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Murine Hind Limb Explant Model

Mechanobiology

Achilles Tendon Impingement

Tendon Cells

Multiaxial Mechanical Strain

Fibrocartilage Phenotype

Glycosaminoglycan GAG

Collagen Network Remodeling

Tendinopathy

Extracellular Environment

Compressive Strain

In Vivo Models

Physical Activity Resumption

Rozdziały w tym wideo

0:00

Introdution

1:31

Explant Dissection to Generate Murine Hind Limb Explant Model to Study Tendon Impingement

3:55

Explant Culture and Platforms Loading to Study the Biologic Sequelae of Tendon Impingement

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