A Hepatocellular Cancer Patient-Derived Organoid Xenograft Model to Investigate Impact of Liver Regeneration on Tumor Growth

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08:15 min

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February 2nd, 2024

DOI :

10.3791/66245-v

February 2nd, 2024

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Fabian Haak*¹, Gabriel Fridolin Hess*¹, Philipp Sedlaczek¹, Savas Deniz Soysal², Jürg Vosbeck³, Salvatore Piscuoglio⁴^,⁵, Mairene Coto-Llerena*⁴, Otto Kollmar*¹

¹Clarunis, Department of Visceral Surgery, University Center for Gastrointestinal and Liver Diseases, St. Clara Hospital and University Hospital Basel, ²Faculty of Medicine, University of Basel, ³Institute of Medical Genetics and Pathology, University Hospital Basel, ⁴Visceral Surgery and Precision Medicine Research Laboratory, Department of Biomedicine, University of Basel, ⁵IRCCS Humanitas Research Hospital

Podsumowanie

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Hepatocellular Carcinoma

Tumor Growth

Liver Regeneration

Organoid Model

Patient derived Organoids

Three dimensional Basement Membrane Matrix

Liver specific Medium

Tumor Explantation

Cancer Research

Rozdziały w tym wideo

0:00

Introduction

1:25

Organoid Formation from Dissociated Human Hepatocarcinoma Cells for Liver Regeneration Research

3:27

Injection of Human Liver Carcinoma Organoids into Mice for Liver Regeneration Study

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Mouse Liver Resectioning for Liver Regeneration Analysis

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