Division of Biology and Biological Engineering
Dr. Wei-Li Wu is an assistant professor in the Department of Physiology at the College of Medicine, National Cheng Kung University. Dr. Wu received his M.S. degree in marine biology with Dr. Hin-Kiu Mok and Dr. Chi-Ying Lee as advisors at National Sun Yat-sen University. Dr. Wu's master's study investigated neurotransmission during aggressive behavior using a fighting fish model. Then Dr. Wu received his Ph.D. degree in neuroscience with Dr. Chih-Cheng Chen as advisor at the Academia Sinica. In the Ph.D. training, he profiled the alternations of emotion-related behaviors in a mouse model with sensory deficits. After completing the doctoral degree, Dr. Wu joined the late Prof. Paul Patterson laboratory at Caltech as a postdoctoral scholar in neuroimmunology from 2012 to 2014. In Patterson laboratory, Dr. Wu focused on the gene x environment interactions in a preclinical mouse model of autism spectrum disorder (ASD) and schizophrenia, maternal immune activation. In 2014, Dr. Wu joined Prof. Sarkis Mazmanian laboratory at Caltech to carry on his works from the Patterson lab and to explore a brand-new direction: understanding how gut microbiota mediate mental homeostasis and disease. In Mazmanian laboratory, Dr. Wu interrogated the microbiota-based neural circuits underlying the social behavior using germ-free and antibiotics-treated mice, the mice deprived of the gut microbiota. In 2018, Dr. Wu set up his laboratory at National Cheng Kung University and continuously worked to unravel the neural mechanism by which gut microbiota impact brain circuits and host behaviors.
Apoptotic effect of As2S2 on K562 cells and its mechanism.
Acta pharmacologica Sinica Nov, 2002 | Pubmed ID: 12421474
[New Retinoid SX-116 Induces Apoptosis of Acute Promyelocytic Leukemia Cell Line NB4]
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology Mar, 2001 | Pubmed ID: 12578641
[Preliminary study on the molecular mechanism of K562 cell apoptosis induced by As2S2].
Zhonghua zhong liu za zhi [Chinese journal of oncology] May, 2003 | Pubmed ID: 12839680
[Studies on the dynamics of biological characteristics of CD133+ cells from human umbilical cord blood during short-term culture].
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology Dec, 2003 | Pubmed ID: 14706136
[Synergism of As2S2 and STI 571 in inducing apoptosis of K562 cells].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi Nov, 2003 | Pubmed ID: 14720443
[Effect of TGF-beta1 on biological characteristics of umbilical cord blood hematopoietic progenitor cells during ex-vivo expansion].
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology Feb, 2004 | Pubmed ID: 14989763
[The reliability and validity of adult attachment scale (AAS-1996 revised edition): a report on its application in China].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition Jul, 2004 | Pubmed ID: 15291121
[Relationship between the adult attachment styles of social anxiety disorder (SAD) and its cognitive mode and behavior mode].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition Mar, 2005 | Pubmed ID: 15807286
No correlation between BRAFV600E mutation and clinicopathological features of papillary thyroid carcinomas in Taiwan.
Clinical endocrinology Oct, 2005 | Pubmed ID: 16181240
Preparation of a novel composite particles and its application in the fluorescent detection of proteins.
Analytical and bioanalytical chemistry Aug, 2006 | Pubmed ID: 16807702
Combined effects of histone deacetylase inhibitor and rituximab on non-Hodgkin's B-lymphoma cells apoptosis.
Experimental hematology Dec, 2007 | Pubmed ID: 17681667
Effect of intracoronary administration of anisodamine on slow reflow phenomenon following primary percutaneous coronary intervention in patients with acute myocardial infarction.
Chinese medical journal Jul, 2007 | Pubmed ID: 17697572
Selective determination of dopamine in the presence of high concentration of ascorbic acid using nano-Au self-assembly glassy carbon electrode.
Colloids and surfaces. B, Biointerfaces Apr, 2008 | Pubmed ID: 18006287
[Influence of intracoronary administration of anisodamine on no-reflow, ventricular function and systolic synchrony in acute myocardial infarction patients undergoing percutaneous coronary intervention].
Zhonghua xin xue guan bing za zhi Oct, 2007 | Pubmed ID: 18206037
Effect of tirofiban plus clopidogrel and aspirin on primary percutaneous coronary intervention via transradial approach in patients with acute myocardial infarction.
Chinese medical journal Mar, 2008 | Pubmed ID: 18364139
An amperometric horseradish peroxidase inhibition biosensor for the determination of phenylhydrazine.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry Jul, 2008 | Pubmed ID: 18614832
[The influence of self-improving based group psychotherapy in defense mechanisms for the clients with social anxiety disorder].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition Nov, 2008 | Pubmed ID: 19253851
Intensive cholesterol lowering with statin improves the outcomes of percutaneous coronary intervention in patients with acute coronary syndrome.
Chinese medical journal Mar, 2009 | Pubmed ID: 19323930
Voltammetric Behavior of o-Nitrophenol and Damage to DNA.
International journal of molecular sciences Mar, 2008 | Pubmed ID: 19325751
[The effect of different dispersive methods on flexural strength nano-ZrO(2) reinforced denture polymethyl methacrylate].
Shanghai kou qiang yi xue = Shanghai journal of stomatology Jun, 2009 | Pubmed ID: 19649533
Asic3(-/-) female mice with hearing deficit affects social development of pups.
PloS one , 2009 | Pubmed ID: 19652708
Equilibrium radionuclide angiography for evaluating the effect of percutaneous coronary intervention on ventricular aneurysm formation and systolic synchrony in patients with acute myocardial infarction.
The international journal of cardiovascular imaging Dec, 2009 | Pubmed ID: 19672689
[Synergistic effects of proteasome inhibitor and histone deacetylase inhibitor on apoptosis and aggresome formation in T lymphoma cells].
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology Oct, 2009 | Pubmed ID: 19840453
Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2010 | Pubmed ID: 20133625
[Expressions of CD147, MMP-2 and MMP-9 in laryngeal carcinoma and clinical significance].
Zhonghua yi xue za zhi May, 2010 | Pubmed ID: 20646600
[The effects of cardiac pacing with multisite combination on myocardial mechanics and cardiac work in dogs].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology Nov, 2003 | Pubmed ID: 21166231
Synergistic effect of bortezomib and valproic acid treatment on the proliferation and apoptosis of acute myeloid leukemia and myelodysplastic syndrome cells.
Annals of hematology Aug, 2011 | Pubmed ID: 21340723
Prediction of contrast-induced nephropathy in diabetics undergoing elective percutaneous coronary intervention: role of the ratio of contrast medium volume to estimated glomerular filtration rate.
Chinese medical journal Mar, 2011 | Pubmed ID: 21518598
[Mammary serine proteinase inhibitor subcellular expression in oral squamous cell carcinoma and its clinical significance].
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology Aug, 2011 | Pubmed ID: 22169751
Targeting ASIC3 for pain, anxiety, and insulin resistance.
Pharmacology & therapeutics May, 2012 | Pubmed ID: 22233754
Equilibrium radionuclide angiography for evaluating the effect of facilitated percutaneous coronary intervention on ventricular synchrony in patients with acute myocardial infarction.
Circulation journal : official journal of the Japanese Circulation Society , 2012 | Pubmed ID: 22313803
Safety and efficacy of anisodamine on prevention of contrast induced nephropathy in patients with acute coronary syndrome.
Chinese medical journal Mar, 2012 | Pubmed ID: 22613532
Randomized comparison of radial versus femoral approach for patients with STEMI undergoing early PCI following intravenous thrombolysis.
The Journal of invasive cardiology Aug, 2012 | Pubmed ID: 22865313
A comparative study of transulnar and transradial artery access for percutaneous coronary intervention in patients with acute coronary syndrome.
Journal of interventional cardiology Oct, 2014 | Pubmed ID: 25250862
Explanatory style differences in health literacy: a survey among young adults in Taiwan.
Psychology, health & medicine Mar, 2016 | Pubmed ID: 25532063
The effects of situated learning and health knowledge involvement on health communications.
Reproductive health , 2014 | Pubmed ID: 25542070
The interaction between maternal immune activation and alpha 7 nicotinic acetylcholine receptor in regulating behaviors in the offspring.
Brain, behavior, and immunity May, 2015 | Pubmed ID: 25683697
EFFECTS OF MEDICAL DISPUTES ON INTERNET COMMUNICATIONS OF NEGATIVE EMOTIONS AND NEGATIVE ONLINE WORD-OF-MOUTH.
Psychological reports Aug, 2015 | Pubmed ID: 26226491
[The volume of residual urine correlates with bladder outlet obstruction and detrusor contractility in patients with benign prostatic hyperplasia].
Zhonghua nan ke xue = National journal of andrology Aug, 2015 | Pubmed ID: 26442302
Bilaterality weighs more than unilateral multifocality in predicting prognosis in papillary thyroid cancer.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine Jan, 2016 | Pubmed ID: 26743781
Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain.
Nature biotechnology Feb, 2016 | Pubmed ID: 26829320
The Protective Role of in a Murine Model of Colitis-Associated Colorectal Cancer.
mSphere 11, 2018 | Pubmed ID: 30429227
The Effect of ASIC3 Knockout on Corticostriatal Circuit and Mouse Self-grooming Behavior.
Frontiers in cellular neuroscience , 2019 | Pubmed ID: 30930747
Microbiota regulate social behaviour via stress response neurons in the brain.
Nature , | Pubmed ID: 34194038
A gut-derived metabolite alters brain activity and anxiety behaviour in mice.
Nature 02, 2022 | Pubmed ID: 35165440
Oral short-chain fatty acids administration regulates innate anxiety in adult microbiome-depleted mice.
Neuropharmacology May, 2022 | Pubmed ID: 35613660
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