Charles F. Mactutus

Cell culture models of oxidative stress and injury in the central nervous system.

Long-term retention of spatial navigation by preweanling rats.

Enduring effects of prenatal cocaine exposure on attention and reaction to errors.

Proximal versus distal cue utilization in spatial navigation: the role of visual acuity?

Proximal versus distal cue utilization in preweanling spatial localization: the influence of cue number and location.

Temporal relationships between HIV-1 Tat-induced neuronal degeneration, OX-42 immunoreactivity, reactive astrocytosis, and protein oxidation in the rat striatum.

Impaired sustained attention and altered reactivity to errors in an animal model of prenatal cocaine exposure.

Prenatal cocaine exposure does not alter working memory in adult rats.

Enduring effects of prenatal cocaine exposure on selective attention and reactivity to errors: evidence from an animal model.

Sex differences and repeated intravenous nicotine: behavioral sensitization and dopamine receptors.

Prenatal intravenous cocaine and the heart rate-orienting response: a dose-response study.

Cocaine-induced inhibition of process outgrowth in locus coeruleus neurons: role of gestational exposure period and offspring sex.

Gonadal steroids differentially modulate neurotoxicity of HIV and cocaine: testosterone and ICI 182,780 sensitive mechanism.

Acute and repeated intravenous cocaine-induced locomotor activity is altered as a function of sex and gonadectomy.

Home cage observations following acute and repeated IV cocaine in intact and gonadectomized rats.

HIV-1 Tat neurotoxicity in primary cultures of rat midbrain fetal neurons: changes in dopamine transporter binding and immunoreactivity.

Cocaine-mediated enhancement of Tat toxicity in rat hippocampal cell cultures: the role of oxidative stress and D1 dopamine receptor.

Neonatal hippocampal Tat injections: developmental effects on prepulse inhibition (PPI) of the auditory startle response.

Prenatal cocaine exposure alters alpha2 receptor expression in adolescent rats.

Neonatal intrahippocampal glycoprotein 120 injection: the role of dopaminergic alterations in prepulse inhibition in adult rats.

Intrahippocampal injections of Tat: effects on prepulse inhibition of the auditory startle response in adult male rats.

Dopaminergic marker proteins in the substantia nigra of human immunodeficiency virus type 1-infected brains.

Microanatomy in 21 day rat brains exposed prenatally to cocaine.

Neonatal intrahippocampal gp120 injection: an examination early in development.

Cocaine exposure in vitro induces apoptosis in fetal locus coeruleus neurons by altering the Bax/Bcl-2 ratio and through caspase-3 apoptotic signaling.

Sex differences in nicotine levels following repeated intravenous injection in rats are attenuated by gonadectomy.

Automation of the novel object recognition task for use in adolescent rats.

Neurotoxicity of HIV-1 Tat protein: involvement of D1 dopamine receptor.

Differential long-term neurotoxicity of HIV-1 proteins in the rat hippocampal formation: a design-based stereological study.

Sex mediates dopamine and adrenergic receptor expression in adult rats exposed prenatally to cocaine.

Effects of chronic adult dietary restriction on spatial learning in the aged F344 x BN hybrid F1 rat.

Neurotoxic profiles of HIV, psychostimulant drugs of abuse, and their concerted effect on the brain: current status of dopamine system vulnerability in NeuroAIDS.

Different effects of selective dopamine uptake inhibitors, GBR 12909 and WIN 35428, on HIV-1 Tat toxicity in rat fetal midbrain neurons.

Neonatal intrahippocampal injection of the HIV-1 proteins gp120 and Tat: differential effects on behavior and the relationship to stereological hippocampal measures.

Neuronal survival and resistance to HIV-1 Tat toxicity in the primary culture of rat fetal neurons.

In vivo microdialysis in awake, freely moving rats demonstrates HIV-1 Tat-induced alterations in dopamine transmission.

The ART of HIV therapies: dopaminergic deficits and future treatments for HIV pediatric encephalopathy.

HIV-1 Tat protein-induced rapid and reversible decrease in [3H]dopamine uptake: dissociation of [3H]dopamine uptake and [3H]2beta-carbomethoxy-3-beta-(4-fluorophenyl)tropane (WIN 35,428) binding in rat striatal synaptosomes.

The human immunodeficiency virus-1-associated protein, Tat1-86, impairs dopamine transporters and interacts with cocaine to reduce nerve terminal function: a no-net-flux microdialysis study.

Dose-dependent long-term effects of Tat in the rat hippocampal formation: a design-based stereological study.

Attenuated neurotoxicity of the transactivation-defective HIV-1 Tat protein in hippocampal cell cultures.

Evidence for developmental dopaminergic alterations in the human immunodeficiency virus-1 transgenic rat.

ER-β mediates 17β-estradiol attenuation of HIV-1 Tat-induced apoptotic signaling.

Hyperdopaminergic tone in HIV-1 protein treated rats and cocaine sensitization.

Prenatal IV nicotine exposure produces a sex difference in sensorimotor gating of the auditory startle reflex in adult rats.

Effect of environmental enrichment on methylphenidate-induced locomotion and dopamine transporter dynamics.

Recombinant human immunodeficiency virus-1 transactivator of transcription1-86 allosterically modulates dopamine transporter activity.

Endogenous amyloidogenesis in long-term rat hippocampal cell cultures.

Prenatal IV Cocaine: Alterations in Auditory Information Processing.

Prenatal cocaine exposure alters progenitor cell markers in the subventricular zone of the adult rat brain.

Adolescent HIV-1 transgenic rats: evidence for dopaminergic alterations in behavior and neurochemistry revealed by methamphetamine challenge.

Soy isoflavones genistein and daidzein exert anti-apoptotic actions via a selective ER-mediated mechanism in neurons following HIV-1 Tat(1-86) exposure.

Environmental enrichment alters nicotine-mediated locomotor sensitization and phosphorylation of DARPP-32 and CREB in rat prefrontal cortex.

Time and time again: temporal processing demands implicate perceptual and gating deficits in the HIV-1 transgenic rat.

HIV-1 Tat protein variants: critical role for the cysteine region in synaptodendritic injury.

Synaptodendritic recovery following HIV Tat exposure: neurorestoration by phytoestrogens.

Modeling deficits in attention, inhibition, and flexibility in HAND.

HIV-1 transgenic female rat: synaptodendritic alterations of medium spiny neurons in the nucleus accumbens.

Neonatal intrahippocampal HIV-1 protein Tat(1-86) injection: neurobehavioral alterations in the absence of increased inflammatory cytokine activation.

Polytocus focus: Uterine position effect is dependent upon horn size.

HIV-1 proteins, Tat and gp120, target the developing dopamine system.

The role of sensory modality in prepulse inhibition: An ontogenetic study.

HIV-1 Tat and cocaine mediated synaptopathy in cortical and midbrain neurons is prevented by the isoflavone Equol.

Intravenous Prenatal Nicotine Exposure Alters METH-Induced Hyperactivity, Conditioned Hyperactivity, and BDNF in Adult Rat Offspring.

Selective developmental alterations in The HIV-1 transgenic rat: Opportunities for diagnosis of pediatric HIV-1.

A Gap in Time: Extending our Knowledge of Temporal Processing Deficits in the HIV-1 Transgenic Rat.

Temporal processsing demands in the HIV-1 transgenic rat: Amodal gating and implications for diagnostics.

Evolution of the HIV-1 transgenic rat: utility in assessing the progression of HIV-1-associated neurocognitive disorders.

Dose-dependent neurocognitive deficits following postnatal day 10 HIV-1 viral protein exposure: Relationship to hippocampal anatomy parameters.

Sex Matters: Robust Sex Differences in Signal Detection in the HIV-1 Transgenic Rat.

HIV-1 and cocaine disrupt dopamine reuptake and medium spiny neurons in female rat striatum.

Unraveling Individual Differences In The HIV-1 Transgenic Rat: Therapeutic Efficacy Of Methylphenidate.

HIV-1 proteins dysregulate motivational processes and dopamine circuitry.

Synaptic Connectivity in Medium Spiny Neurons of the Nucleus Accumbens: A Sex-Dependent Mechanism Underlying Apathy in the HIV-1 Transgenic Rat.

Diagnostic and prognostic biomarkers for HAND.

Disruption of Timing: NeuroHIV Progression in the Post-cART Era.

Posterior ventral tegmental area-nucleus accumbens shell circuitry modulates response to novelty.

Selective monoaminergic and histaminergic circuit dysregulation following long-term HIV-1 protein exposure.

Neurorestoration of Sustained Attention in a Model of HIV-1 Associated Neurocognitive Disorders.

An Empirical Mediation Analysis of Mechanisms Underlying HIV-1-Associated Neurocognitive Disorders.

Selective Estrogen Receptor β Agonists: a Therapeutic Approach for HIV-1 Associated Neurocognitive Disorders.

HIV Infection and Neurocognitive Disorders in the Context of Chronic Drug Abuse: Evidence for Divergent Findings Dependent upon Prior Drug History.

Correction to: HIV Infection and Neurocognitive Disorders in the Context of Chronic Drug Abuse: Evidence for Divergent Findings Dependent upon Prior Drug History.

S-EQUOL: a neuroprotective therapeutic for chronic neurocognitive impairments in pediatric HIV.

Progression of temporal processing deficits in the HIV-1 transgenic rat.

Chronic SSRI treatment reverses HIV-1 protein-mediated synaptodendritic damage.

Microglial HIV-1 Expression: Role in HIV-1 Associated Neurocognitive Disorders.

S-Equol mitigates motivational deficits and dysregulation associated with HIV-1.

HIV-Associated Apathy/Depression and Neurocognitive Impairments Reflect Persistent Dopamine Deficits.

Neurodevelopmental Processes in the Prefrontal Cortex Derailed by Chronic HIV-1 Viral Protein Exposure.

Intraneuronal β-Amyloid Accumulation: Aging HIV-1 Human and HIV-1 Transgenic Rat Brain.

Synaptic dysfunction is associated with alterations in the initiation of goal-directed behaviors: Implications for HIV-1-associated apathy.

Disrupted Decision-Making: EcoHIV Inoculation in Cocaine Dependent Rats.

Microglia proliferation underlies synaptic dysfunction in the prefrontal cortex: implications for the pathogenesis of HIV-1-associated neurocognitive and affective alterations.

Therapeutically targeting the consequences of HIV-1-associated gastrointestinal dysbiosis: Implications for neurocognitive and affective alterations.

HIV-1 mRNA Knockdown with CRISPR/Cas9 Enhances Neurocognitive Function.

SARS-CoV-2 RNA persists in the central nervous system of non-human primates despite clinical recovery.

HIV-1 mRNA knockdown with CRISPR/CAS9 enhances neurocognitive function.

Adolescent oral oxycodone self-administration disrupts neurobehavioral and neurocognitive development.