Department of Functional Genomics and Cancer
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Specific and redundant functions of retinoid X Receptor/Retinoic acid receptor heterodimers in differentiation, proliferation, and apoptosis of F9 embryonal carcinoma cells.
The Journal of cell biology Nov, 1997 | Pubmed ID: 9348290
Spatio-temporally controlled site-specific somatic mutagenesis in the mouse.
Proceedings of the National Academy of Sciences of the United States of America Dec, 1997 | Pubmed ID: 9405652
Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha.
Molecular and cellular biology Aug, 1999 | Pubmed ID: 10409727
Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor alpha mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2001 | Pubmed ID: 11134524
Selective ablation of retinoid X receptor alpha in hepatocytes impairs their lifespan and regenerative capacity.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2001 | Pubmed ID: 11287642
Germ cell expression of the transcriptional co-repressor TIF1beta is required for the maintenance of spermatogenesis in the mouse.
Development (Cambridge, England) May, 2002 | Pubmed ID: 11973266
Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled.
The EMBO journal Jul, 2002 | Pubmed ID: 12093741
Temporally controlled site-specific mutagenesis in the germ cell lineage of the mouse testis.
Biology of reproduction Feb, 2003 | Pubmed ID: 12533419
TAF10 (TAF(II)30) is necessary for TFIID stability and early embryogenesis in mice.
Molecular and cellular biology Jun, 2003 | Pubmed ID: 12773572
Targeted conditional somatic mutagenesis in the mouse: temporally-controlled knock out of retinoid receptors in epidermal keratinocytes.
Methods in enzymology , 2003 | Pubmed ID: 14631857
Retinal dystrophy resulting from ablation of RXR alpha in the mouse retinal pigment epithelium.
The American journal of pathology Feb, 2004 | Pubmed ID: 14742273
Friedreich ataxia mouse models with progressive cerebellar and sensory ataxia reveal autophagic neurodegeneration in dorsal root ganglia.
The Journal of neuroscience : the official journal of the Society for Neuroscience Feb, 2004 | Pubmed ID: 14985441
Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2004 | Pubmed ID: 15070754
Targeted somatic mutagenesis in the mouse epidermis.
Methods in molecular biology (Clifton, N.J.) , 2005 | Pubmed ID: 15502196
Temporally controlled targeted somatic mutagenesis in skeletal muscles of the mouse.
Genesis (New York, N.Y. : 2000) Apr, 2005 | Pubmed ID: 15789425
Temporally controlled targeted somatic mutagenesis in embryonic surface ectoderm and fetal epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis and skin barrier formation.
Development (Cambridge, England) Oct, 2005 | Pubmed ID: 16192310
Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2005 | Pubmed ID: 16199515
Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes.
Genes & development Jun, 2006 | Pubmed ID: 16751185
Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2006 | Pubmed ID: 16880407
Malignant transformation of DMBA/TPA-induced papillomas and nevi in the skin of mice selectively lacking retinoid-X-receptor alpha in epidermal keratinocytes.
The Journal of investigative dermatology May, 2007 | Pubmed ID: 17301838
Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2007 | Pubmed ID: 17556545
The TFIID subunit TAF4 regulates keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity in mouse epidermis.
Development (Cambridge, England) Aug, 2007 | Pubmed ID: 17626060
LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2007 | Pubmed ID: 17670946
Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1.
Molecular and cellular biology Dec, 2007 | Pubmed ID: 17908794
Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha.
Nature genetics Dec, 2007 | Pubmed ID: 18026104
Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2008 | Pubmed ID: 18268330
Expanded CTG repeats within the DMPK 3' UTR causes severe skeletal muscle wasting in an inducible mouse model for myotonic dystrophy.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2008 | Pubmed ID: 18272483
Dual role of COUP-TF-interacting protein 2 in epidermal homeostasis and permeability barrier formation.
The Journal of investigative dermatology Jun, 2009 | Pubmed ID: 19092943
Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2009 | Pubmed ID: 19188585
Myocytic androgen receptor controls the strength but not the mass of limb muscles.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2010 | Pubmed ID: 20660752
The transcriptional coregulators TIF2 and SRC-1 regulate energy homeostasis by modulating mitochondrial respiration in skeletal muscles.
Cell metabolism Nov, 2010 | Pubmed ID: 21035760
Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor.
Cell Apr, 2011 | Pubmed ID: 21496643
Hypoxia-inducible transcription factor 2α promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis.
Hepatology (Baltimore, Md.) Aug, 2011 | Pubmed ID: 21538443
Compensatory regulation of dopamine after ablation of the tyrosine hydroxylase gene in the nigrostriatal projection.
The Journal of biological chemistry Dec, 2011 | Pubmed ID: 22027820
Temporally controlled targeted somatic mutagenesis in mouse eye pigment epithelium.
Genesis (New York, N.Y. : 2000) Nov, 2012 | Pubmed ID: 22730183
Genetically engineered mouse models of prostate cancer.
Molecular oncology Apr, 2013 | Pubmed ID: 23481269
Smoothened is a master regulator of adult liver repair.
The Journal of clinical investigation Jun, 2013 | Pubmed ID: 23563311
Nurr1 expression is regulated by voltage-dependent calcium channels and calcineurin in cultured hippocampal neurons.
Neuroscience letters Jan, 2014 | Pubmed ID: 24291696
Lysine-specific demethylase 1 regulates differentiation onset and migration of trophoblast stem cells.
Nature communications , 2014 | Pubmed ID: 24448552
Acute effect of androgens on maximal force-generating capacity and electrically evoked calcium transient in mouse skeletal muscles.
Steroids Sep, 2014 | Pubmed ID: 24844204
Mammary stem cells have myoepithelial cell properties.
Nature cell biology Oct, 2014 | Pubmed ID: 25173976
Clearance of PML/RARA-bound promoters suffice to initiate APL differentiation.
Blood Dec, 2014 | Pubmed ID: 25258343
Hair follicle dermal stem cells regenerate the dermal sheath, repopulate the dermal papilla, and modulate hair type.
Developmental cell Dec, 2014 | Pubmed ID: 25465495
Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis.
Nature medicine Feb, 2015 | Pubmed ID: 25581517
The orphan nuclear receptor Nur77 is a determinant of myofiber size and muscle mass in mice.
Molecular and cellular biology Apr, 2015 | Pubmed ID: 25605333
A vitamin D receptor selectively activated by gemini analogs reveals ligand dependent and independent effects.
Cell reports Feb, 2015 | Pubmed ID: 25620699
Generation of Spatio-Temporally Controlled Targeted Somatic Mutations in the Mouse.
Current protocols in mouse biology Mar, 2011 | Pubmed ID: 26068987
VDR and gemini ligands.
Oncotarget Oct, 2015 | Pubmed ID: 26356569
Patrolling monocytes control tumor metastasis to the lung.
Science (New York, N.Y.) Nov, 2015 | Pubmed ID: 26494174
The transcriptional coregulator PGC-1β controls mitochondrial function and anti-oxidant defence in skeletal muscles.
Nature communications Dec, 2015 | Pubmed ID: 26674215
SOX4 Is Essential for Prostate Tumorigenesis Initiated by PTEN Ablation.
Cancer research Mar, 2016 | Pubmed ID: 26701805
Muscle expression of a malonyl-CoA-insensitive carnitine palmitoyltransferase-1 protects mice against high-fat/high-sucrose diet-induced insulin resistance.
American journal of physiology. Endocrinology and metabolism Sep, 2016 | Pubmed ID: 27507552
Regeneration of fat cells from myofibroblasts during wound healing.
Science (New York, N.Y.) 02, 2017 | Pubmed ID: 28059714
Nur77 deletion impairs muscle growth during developmental myogenesis and muscle regeneration in mice.
PloS one , 2017 | Pubmed ID: 28170423
Gonad-related factors promote muscle performance gain during postnatal development in male and female mice.
American journal of physiology. Endocrinology and metabolism Jul, 2017 | Pubmed ID: 28351832
The Nuclear Receptor Nr4a1 Acts as a Microglia Rheostat and Serves as a Therapeutic Target in Autoimmune-Driven Central Nervous System Inflammation.
Journal of immunology (Baltimore, Md. : 1950) May, 2017 | Pubmed ID: 28411187
Androgen signaling negatively controls group 2 innate lymphoid cells.
The Journal of experimental medicine Jun, 2017 | Pubmed ID: 28484078
IFN-β-induced reactive oxygen species and mitochondrial damage contribute to muscle impairment and inflammation maintenance in dermatomyositis.
Acta neuropathologica Jun, 2017 | Pubmed ID: 28623559
BRG1-SWI/SNF-dependent regulation of the Wt1 transcriptional landscape mediates epicardial activity during heart development and disease.
Nature communications Jul, 2017 | Pubmed ID: 28737171
Peroxisome proliferator-activated receptor gamma (PPARγ) regulates lactase expression and activity in the gut.
EMBO molecular medicine Sep, 2017 | Pubmed ID: 28947679
LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling.
The Journal of biological chemistry Jan, 2009 | Pubmed ID: 18990694
Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation.
Epigenetics & chromatin Nov, 2010 | Pubmed ID: 21118511
Chromatin remodelling complex dosage modulates transcription factor function in heart development.
Nature communications , 2011 | Pubmed ID: 21304516
Regenerated luminal epithelial cells are derived from preexisting luminal epithelial cells in adult mouse prostate.
Molecular endocrinology (Baltimore, Md.) Nov, 2011 | Pubmed ID: 21940754
Polyphenols prevent ageing-related impairment in skeletal muscle mitochondrial function through decreased reactive oxygen species production.
Experimental physiology Feb, 2013 | Pubmed ID: 22903980
Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue.
Molecular and cellular biology Dec, 2012 | Pubmed ID: 23028044
PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice.
The Journal of clinical investigation Nov, 2012 | Pubmed ID: 23093780
Retinoid signaling in progenitors controls specification and regeneration of the urothelium.
Developmental cell Sep, 2013 | Pubmed ID: 23993789
Skeletal myofiber VEGF is essential for the exercise training response in adult mice.
American journal of physiology. Regulatory, integrative and comparative physiology Apr, 2014 | Pubmed ID: 24523345
LSD1 promotes oxidative metabolism of white adipose tissue.
Nature communications Jun, 2014 | Pubmed ID: 24912735
Brg1 loss attenuates aberrant wnt-signalling and prevents wnt-dependent tumourigenesis in the murine small intestine.
PLoS genetics Jul, 2014 | Pubmed ID: 25010414
Myofiber androgen receptor promotes maximal mechanical overload-induced muscle hypertrophy and fiber type transition in male mice.
Endocrinology Dec, 2014 | Pubmed ID: 25216388
Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling.
The Journal of clinical investigation Feb, 2015 | Pubmed ID: 25574839
Moderate Exercise Allows for shorter Recovery Time in Critical Limb Ischemia.
Frontiers in physiology , 2017 | Pubmed ID: 28790926
The histone code reader Spin1 controls skeletal muscle development.
Cell death & disease Nov, 2017 | Pubmed ID: 29168801
deletion in luminal cells of mature prostate induces replication stress and senescence in vivo.
The Journal of experimental medicine Jun, 2018 | Pubmed ID: 29743291
Diabetes Worsens Skeletal Muscle Mitochondrial Function, Oxidative Stress, and Apoptosis After Lower-Limb Ischemia-Reperfusion: Implication of the RISK and SAFE Pathways?
Frontiers in physiology , 2018 | Pubmed ID: 29872405
Short-Term Fasting Reveals Amino Acid Metabolism as a Major Sex-Discriminating Factor in the Liver.
Cell metabolism Aug, 2018 | Pubmed ID: 29909969
PGC-1β modulates statin-associated myotoxicity in mice.
Archives of toxicology Feb, 2019 | Pubmed ID: 30511338
[How to limit the progression of PTEN-deficient prostatic tumors?].
Medecine sciences : M/S Nov, 2018 | Pubmed ID: 30526823
Senescence controls prostatic neoplasia driven by Pten loss.
Molecular & cellular oncology , 2019 | Pubmed ID: 30788414
Skeletal Muscle-Specific Activation of G Signaling Maintains Glucose Homeostasis.
Diabetes Jun, 2019 | Pubmed ID: 30936140
Aging Exacerbates Ischemia-Reperfusion-Induced Mitochondrial Respiration Impairment in Skeletal Muscle.
Antioxidants (Basel, Switzerland) Jun, 2019 | Pubmed ID: 31181751
Cytosolic sequestration of the vitamin D receptor as a therapeutic option for vitamin D-induced hypercalcemia.
Nature communications Dec, 2020 | Pubmed ID: 33288743
Tyrosine hydroxylase conditional KO mice reveal peripheral tissue-dependent differences in dopamine biosynthetic pathways.
The Journal of biological chemistry , 2021 | Pubmed ID: 33737022
Myod1 and GR coordinate myofiber-specific transcriptional enhancers.
Nucleic acids research May, 2021 | Pubmed ID: 33836079
Single-cell analyses unravel cell type-specific responses to a vitamin D analog in prostatic precancerous lesions.
Science advances Jul, 2021 | Pubmed ID: 34330705
TRPC3 shapes the ER-mitochondria Ca transfer characterizing tumour-promoting senescence.
Nature communications Feb, 2022 | Pubmed ID: 35177596
Hypoxia-mediated stabilization of HIF1A in prostatic intraepithelial neoplasia promotes cell plasticity and malignant progression.
Science advances Jul, 2022 | Pubmed ID: 35867798
Vitamin D Analogs Bearing C-20 Modifications Stabilize the Agonistic Conformation of Non-Responsive Vitamin D Receptor Variants.
International journal of molecular sciences Jul, 2022 | Pubmed ID: 35955580
Hypoxia-inducible factor 1A inhibition overcomes castration resistance of prostate tumors.
EMBO molecular medicine Jun, 2023 | Pubmed ID: 37070472
Androgen receptor coordinates muscle metabolic and contractile functions.
Journal of cachexia, sarcopenia and muscle May, 2023 | Pubmed ID: 37208984
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