Daniel Metzger

Specific and redundant functions of retinoid X Receptor/Retinoic acid receptor heterodimers in differentiation, proliferation, and apoptosis of F9 embryonal carcinoma cells.

Spatio-temporally controlled site-specific somatic mutagenesis in the mouse.

Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha.

Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor alpha mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes.

Selective ablation of retinoid X receptor alpha in hepatocytes impairs their lifespan and regenerative capacity.

Germ cell expression of the transcriptional co-repressor TIF1beta is required for the maintenance of spermatogenesis in the mouse.

Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled.

Temporally controlled site-specific mutagenesis in the germ cell lineage of the mouse testis.

TAF10 (TAF(II)30) is necessary for TFIID stability and early embryogenesis in mice.

Targeted conditional somatic mutagenesis in the mouse: temporally-controlled knock out of retinoid receptors in epidermal keratinocytes.

Retinal dystrophy resulting from ablation of RXR alpha in the mouse retinal pigment epithelium.

Friedreich ataxia mouse models with progressive cerebellar and sensory ataxia reveal autophagic neurodegeneration in dorsal root ganglia.

Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse.

Targeted somatic mutagenesis in the mouse epidermis.

Temporally controlled targeted somatic mutagenesis in skeletal muscles of the mouse.

Temporally controlled targeted somatic mutagenesis in embryonic surface ectoderm and fetal epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis and skin barrier formation.

Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin.

Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes.

Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis.

Malignant transformation of DMBA/TPA-induced papillomas and nevi in the skin of mice selectively lacking retinoid-X-receptor alpha in epidermal keratinocytes.

Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure.

The TFIID subunit TAF4 regulates keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity in mouse epidermis.

LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease.

Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1.

Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha.

Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma.

Expanded CTG repeats within the DMPK 3' UTR causes severe skeletal muscle wasting in an inducible mouse model for myotonic dystrophy.

Dual role of COUP-TF-interacting protein 2 in epidermal homeostasis and permeability barrier formation.

Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma.

Myocytic androgen receptor controls the strength but not the mass of limb muscles.

The transcriptional coregulators TIF2 and SRC-1 regulate energy homeostasis by modulating mitochondrial respiration in skeletal muscles.

Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor.

Hypoxia-inducible transcription factor 2α promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis.

Compensatory regulation of dopamine after ablation of the tyrosine hydroxylase gene in the nigrostriatal projection.

Temporally controlled targeted somatic mutagenesis in mouse eye pigment epithelium.

Genetically engineered mouse models of prostate cancer.

Smoothened is a master regulator of adult liver repair.

Nurr1 expression is regulated by voltage-dependent calcium channels and calcineurin in cultured hippocampal neurons.

Lysine-specific demethylase 1 regulates differentiation onset and migration of trophoblast stem cells.

Acute effect of androgens on maximal force-generating capacity and electrically evoked calcium transient in mouse skeletal muscles.

Mammary stem cells have myoepithelial cell properties.

Clearance of PML/RARA-bound promoters suffice to initiate APL differentiation.

Hair follicle dermal stem cells regenerate the dermal sheath, repopulate the dermal papilla, and modulate hair type.

Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis.

The orphan nuclear receptor Nur77 is a determinant of myofiber size and muscle mass in mice.

A vitamin D receptor selectively activated by gemini analogs reveals ligand dependent and independent effects.

Generation of Spatio-Temporally Controlled Targeted Somatic Mutations in the Mouse.

VDR and gemini ligands.

Patrolling monocytes control tumor metastasis to the lung.

The transcriptional coregulator PGC-1β controls mitochondrial function and anti-oxidant defence in skeletal muscles.

SOX4 Is Essential for Prostate Tumorigenesis Initiated by PTEN Ablation.

Muscle expression of a malonyl-CoA-insensitive carnitine palmitoyltransferase-1 protects mice against high-fat/high-sucrose diet-induced insulin resistance.

Regeneration of fat cells from myofibroblasts during wound healing.

Nur77 deletion impairs muscle growth during developmental myogenesis and muscle regeneration in mice.

Gonad-related factors promote muscle performance gain during postnatal development in male and female mice.

The Nuclear Receptor Nr4a1 Acts as a Microglia Rheostat and Serves as a Therapeutic Target in Autoimmune-Driven Central Nervous System Inflammation.

Androgen signaling negatively controls group 2 innate lymphoid cells.

IFN-β-induced reactive oxygen species and mitochondrial damage contribute to muscle impairment and inflammation maintenance in dermatomyositis.

BRG1-SWI/SNF-dependent regulation of the Wt1 transcriptional landscape mediates epicardial activity during heart development and disease.

Peroxisome proliferator-activated receptor gamma (PPARγ) regulates lactase expression and activity in the gut.

LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling.

Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation.

Chromatin remodelling complex dosage modulates transcription factor function in heart development.

Regenerated luminal epithelial cells are derived from preexisting luminal epithelial cells in adult mouse prostate.

Polyphenols prevent ageing-related impairment in skeletal muscle mitochondrial function through decreased reactive oxygen species production.

Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue.

PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice.

Retinoid signaling in progenitors controls specification and regeneration of the urothelium.

Skeletal myofiber VEGF is essential for the exercise training response in adult mice.

LSD1 promotes oxidative metabolism of white adipose tissue.

Brg1 loss attenuates aberrant wnt-signalling and prevents wnt-dependent tumourigenesis in the murine small intestine.

Myofiber androgen receptor promotes maximal mechanical overload-induced muscle hypertrophy and fiber type transition in male mice.

Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling.

Moderate Exercise Allows for shorter Recovery Time in Critical Limb Ischemia.

The histone code reader Spin1 controls skeletal muscle development.

deletion in luminal cells of mature prostate induces replication stress and senescence in vivo.

Diabetes Worsens Skeletal Muscle Mitochondrial Function, Oxidative Stress, and Apoptosis After Lower-Limb Ischemia-Reperfusion: Implication of the RISK and SAFE Pathways?

Short-Term Fasting Reveals Amino Acid Metabolism as a Major Sex-Discriminating Factor in the Liver.

PGC-1β modulates statin-associated myotoxicity in mice.

[How to limit the progression of PTEN-deficient prostatic tumors?].

Senescence controls prostatic neoplasia driven by Pten loss.

Skeletal Muscle-Specific Activation of G Signaling Maintains Glucose Homeostasis.

Aging Exacerbates Ischemia-Reperfusion-Induced Mitochondrial Respiration Impairment in Skeletal Muscle.

Cytosolic sequestration of the vitamin D receptor as a therapeutic option for vitamin D-induced hypercalcemia.

Tyrosine hydroxylase conditional KO mice reveal peripheral tissue-dependent differences in dopamine biosynthetic pathways.

Myod1 and GR coordinate myofiber-specific transcriptional enhancers.

Single-cell analyses unravel cell type-specific responses to a vitamin D analog in prostatic precancerous lesions.

TRPC3 shapes the ER-mitochondria Ca transfer characterizing tumour-promoting senescence.

Hypoxia-mediated stabilization of HIF1A in prostatic intraepithelial neoplasia promotes cell plasticity and malignant progression.

Vitamin D Analogs Bearing C-20 Modifications Stabilize the Agonistic Conformation of Non-Responsive Vitamin D Receptor Variants.

Hypoxia-inducible factor 1A inhibition overcomes castration resistance of prostate tumors.

Androgen receptor coordinates muscle metabolic and contractile functions.