Shandong Provincial Key Laboratory of Oral Tissue Regeneration and Laboratory for Tissue Engineering and Regeneration,
School of Stomatology,
Shandong Provincial Key Laboratory of Oral Tissue Regeneration and Laboratory for Tissue Engineering and Regeneration, School of Stomatology
Dr. Xunwei Wu is a Principal Investigator in Shandong Provincial Key Laboratory of Oral Biomedicine and Laboratory for Tissue Engineering and Regeneration, School of Stomatology, Shandong University, Jinan, Shandong, China. He received his bachelor’s degree from Zhejiang University and a Ph.D. from Fudan University, Shanghai, China.
Dr. Wu did his first postdoctoral training at Max-Planck-Institute of Biochemistry, Germany, he generated skin conditional knockout mouse model for studying skin/hair development in vivo. And for the second postdoctoral training at Harvard Medical School, he established a novel in vivo cyst assay to study the function of human keratinocytes in vivo.
His research group currently focuses on in vivo human skin regeneration by using culture-expanded cells. Recently, his group established a new system to efficiently isolate and culture skin stem cell including both epidermal and dermal cells, and the culture system could maintain in vivo regeneration potential of skin cells after expansion. By using the culture-expanded cells, his group generated a novel mouse model with a full-thickness human skin containing mature cycling hair follicle, and the model that showed the wound healing procedure of the regenerate skin was similar to that of normal human skin. The new mouse model with regeneration of human skin provides a platform to study human skin diseases including in vivo aging process and underlying mechanisms.
An advanced mouse model for human skin wound healing.
Experimental dermatology 05, 2017 | Pubmed ID: 27892608
The patch assay reconstitutes mature hair follicles by culture-expanded human cells.
Regenerative medicine 07, 2017 | Pubmed ID: 28749726
Y-27632 simplifies the isolation procedure of human primary epidermal cells by selectively blocking focal adhesion of dermal cells.
Journal of tissue engineering and regenerative medicine Feb, 2018 | Pubmed ID: 28752652
The Basic Mechanism of Hair Growth Stimulation by Adipose-derived Stem Cells and Their Secretory Factors.
Current stem cell research & therapy , 2017 | Pubmed ID: 28875863
Negative Regulation of Skin Pigmentation in Three-Dimensional Reconstructs by Adipose-Derived Mesenchymal Cells.
The Journal of investigative dermatology Dec, 2017 | Pubmed ID: 29169460
One-Step Simple Isolation Method to Obtain Both Epidermal and Dermal Stem Cells from Human Skin Specimen.
Methods in molecular biology (Clifton, N.J.) Feb, 2018 | Pubmed ID: 29478135
The ARE-binding protein Tristetraprolin (TTP) is a novel target and mediator of calcineurin tumor suppressing function in the skin.
PLoS genetics 05, 2018 | Pubmed ID: 29723192
Dissociated skin cells regenerate hair follicles in a microwound, "The Punch Assay".
Experimental dermatology Jul, 2018 | Pubmed ID: 30033549
ROCK inhibitor enhances the growth and migration of BRAF mutant skin melanoma cells.
Cancer science Aug, 2018 | Pubmed ID: 30168234
Human Reconstructed Skin in a Mouse Model.
Methods in molecular biology (Clifton, N.J.) , 2019 | Pubmed ID: 31148091
Y-27632 preserves epidermal integrity in a human skin organ-culture (hSOC) system by regulating AKT and ERK signaling pathways.
Journal of dermatological science Nov, 2019 | Pubmed ID: 31718896
Pre-aggregation of scalp progenitor dermal and epidermal stem cells activates the WNT pathway and promotes hair follicle formation in in vitro and in vivo systems.
Stem cell research & therapy 12, 2019 | Pubmed ID: 31856904
Phenformin promotes keratinocyte differentiation via the calcineurin/NFAT pathway.
The Journal of investigative dermatology Jun, 2020 | Pubmed ID: 32619504
Early-stage bilayer tissue-engineered skin substitute formed by adult skin progenitor cells produces an improved skin structure in vivo.
Stem cell research & therapy 09, 2020 | Pubmed ID: 32948249
ATF-3 expression inhibits melanoma growth by downregulating ERK and AKT pathways.
Laboratory investigation; a journal of technical methods and pathology 05, 2021 | Pubmed ID: 33299127
A carbazole compound, 9-ethyl-9H-carbazole-3-carbaldehyde, plays an antitumor function through reactivation of the p53 pathway in human melanoma cells.
Cell death & disease 06, 2021 | Pubmed ID: 34103468
Inhibition of Calcineurin/NFAT Signaling Blocks Oncogenic H-Ras Induced Autophagy in Primary Human Keratinocytes.
Frontiers in cell and developmental biology , 2021 | Pubmed ID: 34350189
Exosomes derived from stem cells of human deciduous exfoliated teeth inhibit angiogenesis in vivo and in vitro via the transfer of miR-100-5p and miR-1246.
Stem cell research & therapy Mar, 2022 | Pubmed ID: 35241153
Exosomes Derived From Hypoxia-Conditioned Stem Cells of Human Deciduous Exfoliated Teeth Enhance Angiogenesis the Transfer of let-7f-5p and miR-210-3p.
Frontiers in cell and developmental biology , 2022 | Pubmed ID: 35557954
CUL4B Upregulates RUNX2 to Promote the Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Epigenetically Repressing the Expression of miR-320c and miR-372/373-3p.
Frontiers in cell and developmental biology , 2022 | Pubmed ID: 35784474
Phenformin Down-Regulates c-Myc Expression to Suppress the Expression of Pro-Inflammatory Cytokines in Keratinocytes.
Cells Aug, 2022 | Pubmed ID: 35954273
Phenformin suppresses angiogenesis through the regulation of exosomal microRNA-1246 and microRNA-205 levels derived from oral squamous cell carcinoma cells.
Frontiers in oncology , 2022 | Pubmed ID: 36158698
Identification of a new way to induce differentiation of dermal fibroblasts into vascular endothelial cells.
Stem cell research & therapy Oct, 2022 | Pubmed ID: 36210433
HOCI Probe CPP Induces the Differentiation of Human Dermal Fibroblasts into Vascular Endothelial Cells through PHD2/HIF-1α/HEY1 Signaling Pathway.
Cells Oct, 2022 | Pubmed ID: 36231088
Rete ridges: Morphogenesis, function, regulation, and reconstruction.
Acta biomaterialia Jan, 2023 | Pubmed ID: 36427683
Constructing epidermal rete ridges using a composite hydrogel to enhance multiple signaling pathways for the maintenance of epidermal stem cell niche.
Acta biomaterialia Oct, 2023 | Pubmed ID: 37516415
miR-21 Expressed by Dermal Fibroblasts Enhances Skin Wound Healing Through the Regulation of Inflammatory Cytokine Expression.
Inflammation Dec, 2023 | Pubmed ID: 38041730
Chang Liu1,
Shuangshuang Wang1,
Man Liu2,
Fuxiang Bai1,
Zhihong Chen3,
Ping Wang4,
Jun Mi1,5,
Xunwei Wu1
1Department of Tissue Engineering and Regeneration, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration,
2, Shijiazhuang Shimen Experimental School,
3, Qilu Children's Hospital of Shandong University,
4, Qilu Hospital of Shandong University,
5, Shenzhen Research Institute of Shandong University
Zhiwei Xie1,2,3,
Jizhou Shi4,
Min Zong3,
Qiuping Xu1,
Chang Liu1,
Jie Wen1,
Qun Zhang1,
Panpan Liu1,
Guanyi Liu1,
Jing Guo2,5,
Xunwei Wu1
1Department of Tissue Engineering and Regeneration, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration,
2Department of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration,
3Department of Stomatology, Shengli Oilfield Central Hospital,
4Department of Pediatric Surgery, Shengli Oilfield Central Hospital,
5Ningbo Stomatology Hospital of Savaid Stomatology School, Hangzhou Medical College
Linfeng Qian*,1,
Jiaxi Yan*,1,
Shiqi Chen1,
Maryam Mohanmmed Abbas Karekad2,
Yue Wu3,4,
Xunwei Wu5,
Xiaohong Xu3,4,
Xiaoqun Zhang6,7
1, The First Clinical Medical College of Zhejiang Chinese Medical University,
2, The International Education College of Zhejiang Chinese Medical University,
3Department of Breast Surgery, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine),
4, Bozhou District Hospital of Traditional Chinese Medicine,
5Engineering Laboratory for Biomaterials and Tissue Regeneration, Ningbo Stomatology Hospital, Ningbo, China and Savaid Stomatology School, Hangzhou Medical College,
6Department of Surgery, Kaihua District, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine),
7, Kaihua County Hospital of Traditional Chinese Medicine
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