Robin J. M. Franklin

Transplanting oligodendrocyte progenitors into the adult CNS.

What roles do growth factors play in CNS remyelination?

Recognition and diagnosis of lysosomal storage diseases in the cat and dog.

The age-related decrease in CNS remyelination efficiency is attributable to an impairment of both oligodendrocyte progenitor recruitment and differentiation.

Ageing and CNS remyelination.

Remyelination of the demyelinated CNS: the case for and against transplantation of central, peripheral and olfactory glia.

Why does remyelination fail in multiple sclerosis?

Expression of the POU-domain transcription factors SCIP/Oct-6 and Brn-2 is associated with Schwann cell but not oligodendrocyte remyelination of the CNS.

Transplant mediated repair of the central nervous system: an imminent solution?

Meningeal cells enhance limited CNS remyelination by transplanted olfactory ensheathing cells.

Lentiviral vectors for gene delivery to normal and demyelinated white matter.

Remyelination by transplanted olfactory ensheathing cells.

Impaired remyelination and depletion of oligodendrocyte progenitors does not occur following repeated episodes of focal demyelination in the rat central nervous system.

Quantifying the early stages of remyelination following cuprizone-induced demyelination.

Increasing local levels of neuregulin (glial growth factor-2) by direct infusion into areas of demyelination does not alter remyelination in the rat CNS.

Olfactory ensheathing cells induce less host astrocyte response and chondroitin sulphate proteoglycan expression than Schwann cells following transplantation into adult CNS white matter.

CNS axons retain their competence for myelination throughout life.

Neuroscience. The mysteries of myelin unwrapped.

Notch1 and Jagged1 are expressed after CNS demyelination, but are not a major rate-determining factor during remyelination.

Increased expression of Nkx2.2 and Olig2 identifies reactive oligodendrocyte progenitor cells responding to demyelination in the adult CNS.

Superparamagnetic iron oxide-labeled Schwann cells and olfactory ensheathing cells can be traced in vivo by magnetic resonance imaging and retain functional properties after transplantation into the CNS.

Minocycline-mediated inhibition of microglia activation impairs oligodendrocyte progenitor cell responses and remyelination in a non-immune model of demyelination.

Macrophage-depletion induced impairment of experimental CNS remyelination is associated with a reduced oligodendrocyte progenitor cell response and altered growth factor expression.

Mechanisms of CNS remyelination--the key to therapeutic advances.

Differences in the early inflammatory responses to toxin-induced demyelination are associated with the age-related decline in CNS remyelination.

Stem cells, progenitors and myelin repair.

Autologous olfactory glial cell transplantation is reliable and safe in naturally occurring canine spinal cord injury.

Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiation.

Oligodendrocyte progenitor cell (OPC) transplantation is unlikely to offer a means of preventing X-irradiation induced damage in the CNS.

Corticosteroids delay remyelination of experimental demyelination in the rodent central nervous system.

Magnetic resonance imaging of functional Schwann cell transplants labelled with magnetic microspheres.

Comparison of cell populations derived from canine olfactory bulb and olfactory mucosal cultures.

Females remyelinate more efficiently than males following demyelination in the aged but not young adult CNS.

Inflammation stimulates myelination by transplanted oligodendrocyte precursor cells.

Cdc42 and Rac1 signaling are both required for and act synergistically in the correct formation of myelin sheaths in the CNS.

Calponin is expressed by fibroblasts and meningeal cells but not olfactory ensheathing cells in the adult peripheral olfactory system.

Mutations in genes causing human familial isolated hyperparathyroidism do not account for hyperparathyroidism in Keeshond dogs.

Myelin repair: the role of stem and precursor cells in multiple sclerosis.

Myelin regeneration in demyelinating disorders: new developments in biology and clinical pathology.

Promoting remyelination in multiple sclerosis by endogenous adult neural stem/precursor cells: defining cellular targets.

Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development.

Development of a universal measure of quadrupedal forelimb-hindlimb coordination using digital motion capture and computerised analysis.

Contrasting effects of basic fibroblast growth factor and epidermal growth factor on mouse neonatal olfactory mucosa cells.

The biology of CNS remyelination: the key to therapeutic advances.

Serum-free medium provides a clinically relevant method to increase olfactory ensheathing cell numbers in olfactory mucosa cell culture.

Taking ageing into account in remyelination-based therapies for multiple sclerosis.

Osteopontin is extensively expressed by macrophages following CNS demyelination but has a redundant role in remyelination.

An experimental model of secondary progressive multiple sclerosis that shows regional variation in gliosis, remyelination, axonal and neuronal loss.

Remyelination in the CNS: from biology to therapy.

Quantification of deficits in lateral paw positioning after spinal cord injury in dogs.

Zebrafish myelination: a transparent model for remyelination?

Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency.

Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling.

Transplanted oligodendrocyte precursor cells reduce neurodegeneration in a model of glaucoma.

Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS.

Remyelination - An effective means of neuroprotection.

Up-regulation of oligodendrocyte precursor cell alphaV integrin and its extracellular ligands during central nervous system remyelination.

Temporal dynamics of myelination in the zebrafish spinal cord.

FGF but not EGF induces phosphorylation of the cAMP response element binding protein in olfactory mucosa-derived cell cultures.

Drug reprofiling using zebrafish identifies novel compounds with potential pro-myelination effects.

CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination.

Mechanical difference between white and gray matter in the rat cerebellum measured by scanning force microscopy.

Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination.

Retinoid X receptor gamma signaling accelerates CNS remyelination.

Genetically induced adult oligodendrocyte cell death is associated with poor myelin clearance, reduced remyelination, and axonal damage.

Regenerative medicine in multiple sclerosis: identifying pharmacological targets of adult neural stem cell differentiation.

Increased mitochondrial content in remyelinated axons: implications for multiple sclerosis.

Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination.

Myelin regeneration in multiple sclerosis: targeting endogenous stem cells.

Neurite outgrowth inhibitor Nogo-A establishes spatial segregation and extent of oligodendrocyte myelination.

Rejuvenation of regeneration in the aging central nervous system.

Mechanical environment modulates biological properties of oligodendrocyte progenitor cells.

Accelerated axonal loss following acute CNS demyelination in mice lacking protein tyrosine phosphatase receptor type Z.

Neuroprotection and repair in multiple sclerosis.

Embryonic-derived olfactory ensheathing cells remyelinate focal areas of spinal cord demyelination more efficiently than neonatal or adult-derived cells.

Autologous olfactory mucosal cell transplants in clinical spinal cord injury: a randomized double-blinded trial in a canine translational model.

Current status of myelin replacement therapies in multiple sclerosis.

Do your glial cells make you clever?

Identification of endothelin 2 as an inflammatory factor that promotes central nervous system remyelination.

Myokymia and neuromyotonia in veterinary medicine: a comparison with peripheral nerve hyperexcitability syndrome in humans.

Neural precursor cells cultured at physiologically relevant oxygen tensions have a survival advantage following transplantation.

Ageing stem and progenitor cells: implications for rejuvenation of the central nervous system.

Peroxisome proliferator-activated receptor gamma-coactivator-1 alpha coordinates sphingolipid metabolism, lipid raft composition and myelin protein synthesis.

The late response of rat subependymal zone stem and progenitor cells to stroke is restricted to directly affected areas of their niche.

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination.

Inhibition of phosphodiesterase-4 promotes oligodendrocyte precursor cell differentiation and enhances CNS remyelination.

Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes.

Cell therapy for spinal cord injuries: what is really going on?

The translational biology of remyelination: past, present, and future.

Auxetic nuclei in embryonic stem cells exiting pluripotency.

Multiple sclerosis genetics.

Special issue on stem cells: "the end of the beginning".

Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis.

Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression.

The EIIIA domain from astrocyte-derived fibronectin mediates proliferation of oligodendrocyte progenitor cells following CNS demyelination.

Demyelination causes adult CNS progenitors to revert to an immature state and express immune cues that support their migration.

Lesion-induced accumulation of platelets promotes survival of adult neural stem / progenitor cells.

The Complement Receptor C5aR Controls Acute Inflammation and Astrogliosis following Spinal Cord Injury.

Fibroblast growth factor signaling in oligodendrocyte-lineage cells facilitates recovery of chronically demyelinated lesions but is redundant in acute lesions.

Glia Disease and Repair-Remyelination.

Regenerative Medicines for Remyelination: From Aspiration to Reality.

Astrocyte Activation via Stat3 Signaling Determines the Balance of Oligodendrocyte versus Schwann Cell Remyelination.

Sox2 Sustains Recruitment of Oligodendrocyte Progenitor Cells following CNS Demyelination and Primes Them for Differentiation during Remyelination.

Discovery of a novel neuroprotectant, BHDPC, that protects against MPP+/MPTP-induced neuronal death in multiple experimental models.

Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyte progenitors.

Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination.

Neuronal expression of pathological tau accelerates oligodendrocyte progenitor cell differentiation.

Vitamin D receptor-retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation.

Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination.

Pioglitazone regulates myelin phagocytosis and multiple sclerosis monocytes.

Pre-Existing Mature Oligodendrocytes Do Not Contribute to Remyelination following Toxin-Induced Spinal Cord Demyelination.

Functional Characterization of DNA Methylation in the Oligodendrocyte Lineage.

Developmental Origin of Oligodendrocyte Lineage Cells Determines Response to Demyelination and Susceptibility to Age-Associated Functional Decline.

Erratum to: Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination.

CNS Remyelination and the Innate Immune System.

Axonal plasticity underpins the functional recovery following surgical decompression in a rat model of cervical spondylotic myelopathy.

Electric Signals Regulate the Directional Migration of Oligodendrocyte Progenitor Cells (OPCs) via β1 Integrin.

MRI measurements of reporter-mediated increases in transmembrane water exchange enable detection of a gene reporter.

Unexpected central role of the androgen receptor in the spontaneous regeneration of myelin.

Subependymal Zone-Derived Oligodendroblasts Respond to Focal Demyelination but Fail to Generate Myelin in Young and Aged Mice.

Regulatory T cells promote myelin regeneration in the central nervous system.

Efficient Remyelination Requires DNA Methylation.

Erratum to: Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination.

Recruitment of endogenous CNS stem cells for regeneration in demyelinating disease.

Do Not Adjust Your Mind: The Fault Is in Your Glia.

Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination.

Serum-Free Medium Provides a Clinically Relevant Method to Increase Olfactory Ensheathing Cell Numbers in Olfactory Mucosa Cell Culture.

Regenerating CNS myelin - from mechanisms to experimental medicines.

Clemastine rescues myelination defects and promotes functional recovery in hypoxic brain injury.

A Subpopulation of Foxj1-Expressing, Nonmyelinating Schwann Cells of the Peripheral Nervous System Contribute to Schwann Cell Remyelination in the Central Nervous System.

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes.

Toxin-Based Models to Investigate Demyelination and Remyelination.

Transforming growth factor-beta renders ageing microglia inhibitory to oligodendrocyte generation by CNS progenitors.

SUMOylation promotes survival and integration of neural stem cell grafts in ischemic stroke.

Diversity in the oligodendrocyte lineage: Plasticity or heterogeneity?

Pericytes Favor Oligodendrocyte Fate Choice in Adult Neural Stem Cells.

Aging restricts the ability of mesenchymal stem cells to promote the generation of oligodendrocytes during remyelination.

Neuronal vulnerability and multilineage diversity in multiple sclerosis.

Niche stiffness underlies the ageing of central nervous system progenitor cells.

Author Correction: Niche stiffness underlies the ageing of central nervous system progenitor cells.

Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells.

Oligodendrocyte Death in Pelizaeus-Merzbacher Disease Is Rescued by Iron Chelation.

The microbiota regulates murine inflammatory responses to toxin-induced CNS demyelination but has minimal impact on remyelination.

Astrocyte Unfolded Protein Response Induces a Specific Reactivity State that Causes Non-Cell-Autonomous Neuronal Degeneration.

The fatty acid binding protein FABP7 is required for optimal oligodendrocyte differentiation during myelination but not during remyelination.

Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system.

Correction to: Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system.

Problems and Pitfalls of Identifying Remyelination in Multiple Sclerosis.

Changes in the Oligodendrocyte Progenitor Cell Proteome with Ageing.

Enhanced axonal response of mitochondria to demyelination offers neuroprotection: implications for multiple sclerosis.

The Role of Astrocytes in Remyelination.

Revisiting remyelination: Towards a consensus on the regeneration of CNS myelin.

Schwann cell remyelination of the central nervous system: why does it happen and what are the benefits?

Genome-wide meta-analysis, fine-mapping and integrative prioritization implicate new Alzheimer's disease risk genes.

Author Correction: Genome-wide meta-analysis, fine-mapping and integrative prioritization implicate new Alzheimer's disease risk genes.

Neuroprotective effects of Sonic hedgehog agonist SAG in a rat model of neonatal stroke.

A map of transcriptional heterogeneity and regulatory variation in human microglia.

Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence.

Diversity of Reactive Astrogliosis in CNS Pathology: Heterogeneity or Plasticity?

Safety and efficacy of bexarotene in patients with relapsing-remitting multiple sclerosis (CCMR One): a randomised, double-blind, placebo-controlled, parallel-group, phase 2a study.

Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain.

Remyelination in humans due to a retinoid-X receptor agonist is age-dependent.

Axonal response of mitochondria to demyelination and complex IV activity within demyelinated axons in experimental models of multiple sclerosis.

Ageing and multiple sclerosis.

CNS remyelination and inflammation: From basic mechanisms to therapeutic opportunities.

Cell-free DNA-based liquid biopsies in neurology.

SARM1 detection in myelinating glia: / is dispensable for PNS and CNS myelination in zebrafish and mice.

Myc determines the functional age state of oligodendrocyte progenitor cells.

Targeted evolution of adeno-associated virus capsids for systemic transgene delivery to microglia and tissue-resident macrophages.

Remyelination in the Central Nervous System.