Synthesis of (6R)-1-[(R)-1-Phenylethyl)-1-Azoniabicyclo[4.1.0]Heptane Tosylate
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General Procedure for the Expansion of 1-Azoniabicyclo[4.1.0]Heptane Tosylate
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Synthesis of (S)-1-[(R)-1-Phenylethyl]azepan-3-ol
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Synthesis of [(2R,3R,4R)-3,4-Bis(Benzyloxy)-1-(S)-1-Phenylethyl)Piperidin-2-Yl]Methyl Acetate
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Results: Synthesis and Characterization of Bicyclic Aziridinium Ions and its Ring Expansion to Azaheterocycles
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Conclusion
Transcrição
This method can help to answer key questions in the field of bicyclic aziridinium ion chemistry for the synthesis of various various azaheterocycles including bipyridine and azepine ring systems. The main advantage of this technique is that the sy
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Bicyclic aziridinium ions such as 1-azoniabicyclo[4.1.0]heptane tosylate were generated from 2-[4-tolenesulfonyloxybutyl]aziridine, which was utilized for the preparation of substituted piperidines and azepanes via regio- and stereospecific ring-expansion with various nucleophiles. This highly efficient protocol allowed us to prepare diverse azaheterocycles including natural products such as fagomine, febrifugine analogue and balanol.