Synthesis of Spirocyclic Oximes (1‐Oxa‐7‐azaspiro[4.4]nonane) Using a REM Linker and Intramolecular Silyl Nitronate‐Olefin Cycloaddition
4:12
Results: Synthesis of Spirocyclic Oximes
4:38
Conclusion
Transcrição
This solid-phase organic synthetic technique may find applications in the construction of a combinatorial library, while synthesis of het spirocyclic heterocycles, which can be tested for anti-cancer activities using bioassays. Though this method
Faça login ou inicie seu teste gratuito para acessar este conteúdo
Here we present a protocol to demonstrate an efficient method for the synthesis of spirocyclic heterocycles. The five-step process utilizes solid-phase synthesis and regenerating Michael linker strategies. Generally difficult to synthesize, we present a customizable method for the synthesis of spirocyclic molecules otherwise inaccessible to other modern approaches.