Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease

DOI :

10.3791/60083-v

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March 17th, 2020

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7,529 Views

Hung D. Nguyen^1*, Phung Thanh Huong^2*, Krystal Hossack¹, Sanjeev Gurshaney¹, Kevin Ezhakunnel¹, Thien-Huong Huynh¹, Anamaria Morales Alvarez¹, Nhat-Tu Le³, Hung N. Luu^4,5

¹Cancer Division, Burnett School of Biomedical Sciences, University of Central Florida, ²Department of Biochemistry, Hanoi University of Pharmacy, ³Center for Cardiovascular Regeneration, Department of Cardiovascular Sciences, Houston Methodist Research Institute, ⁴Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, ⁵Division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center, Hillman Cancer Center

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Graft-versus-host disease is a major complication after allogeneic bone marrow transplantation. Dendritic cells play a critical role in the pathogenesis of graft-versus-host disease. The current article describes a novel bone marrow transplantation platform to investigate the role of dendritic cells in the development of graft-versus-host disease and the graft-versus-leukemia effect.

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