Results: Masarimycin as a Chemical Probe in Synergy/Antagonism Assays and Morphological Studies of Gram-Positive Microorganisms
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Conclusion
TRANSCRIÇÃO
Masarimycin is one of the few inhibitors of bacterial autolysins that halts bacterial cell growth. It can be used to investigate the differences between chemical and genetic inactivation of autolysins, and provides an orthogonal approach to geneti
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A detailed protocol is presented for preparing the bacteriostatic diamide masarimycin, a small molecule probe that inhibits the growth of Bacillus subtilis and Streptococcus pneumoniae by targeting cell wall degradation. Its application as a chemical probe is demonstrated in synergy/antagonism assays and morphological studies with B. subtilis and S. pneumoniae.