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Chapter 4

Pharmacodynamics

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Принципы действия препарата

Drugs are chemical substances that modify biological responses by interacting with macromolecular targets such as receptors, ion channels, transporters, ...

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Целевые показатели для действий с применением лекарственных средств: обзор

Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes. ...

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Передача сигналов: обзор

Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as ...

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Механизм преобразователя: рецепторы, сопряженные с G-белком

G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate ...

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Лиганд-зависимый рецептор ионного канала: механизм стробирования

Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow ...

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Механизм преобразователя: фермент-сцепленные рецепторы

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. ...

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Механизм преобразователя: ядерные рецепторы

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, ...

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Зависимость «доза-реакция»: обзор

Agonists can bind with and activate receptors, resulting in the formation of drug-receptor complexes. Once formed, these complexes catalyze many ...

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Зависимость доза-реакция: активность и эффективность

The potency of a drug is the measure of its ability to produce a biological response and can be compared by looking at the half-maximum effective ...

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Зависимость доза-реакция: селективность и специфичность

Drugs exert their therapeutic effects by interacting with receptors, enzymes, or ion channels that are present throughout the human body. The strength and ...

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Терапевтический индекс

The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose ...

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Лекарственно-рецепторное взаимодействие: агонист

Agonists are drugs that interact with specific receptors in the body to produce a biological response. When an agonist binds to a receptor, it activates ...

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Лекарственно-рецепторное взаимодействие: антагонист

An antagonist is a drug that binds strongly to a receptor without activating it. An antagonist prevents other molecules, such as neurotransmitters or ...

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Комбинированное воздействие наркотиков: антагонизм

The combined effects of drugs can result in various interactions, of which an important type is antagonism. Antagonism is a mechanism where one drug ...

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Комбинированное действие лекарственных препаратов: синергизм

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called ...

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Запасные рецепторы

Some receptors remain unoccupied even when an agonist produces a maximal response. Such empty ones are called spare receptors. In presence of spare ...

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Количественные аспекты лекарственно-рецепторного взаимодействия

The receptor occupancy theory connects a drug's response to the number of occupied receptors. With higher drug concentrations, more receptors are ...

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Модель рецептора с двумя состояниями

The two-state receptor model explains a drug's interaction with receptors, such as G protein-coupled receptors and ligand-gated ion channels, to ...

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Десенсибилизация и тахифилаксия

Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon ...

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