Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
These medications are typically administered orally, making them easier to use than inhalation therapies. This ease of use enhances patient compliance, especially in children who struggle with inhalers or nebulizers.
While leukotriene modifiers are generally safe and well-tolerated, they can cause some adverse effects. These might include headache, nausea, abdominal pain, and cough in adults. Rarely, they may cause psychological effects such as mood changes and nightmares. If these occur, they should be reported promptly to a healthcare professional for evaluation and management.
In children, potential side effects may include nausea, diarrhea, sinusitis, and viral infections. Parents or caregivers should monitor for these symptoms and consult a healthcare provider if they arise. Despite these potential side effects, leukotriene modifiers remain a valuable tool in the arsenal of medications for managing chronic asthma.
From Chapter 19:
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