Ian Parker

A Preliminary Study of the Spreading of AKD in the Presence of Capillary Structures.

Structural and functional relationships between Ca2+ puffs and mitochondria in Xenopus oocytes.

Two-photon imaging of lymphocyte motility and antigen response in intact lymph node.

Intracellular trafficking and membrane targeting mechanisms of the human reduced folate carrier in Mammalian epithelial cells.

Two-photon imaging in intact lymphoid tissue.

Two-photon tissue imaging: seeing the immune system in a fresh light.

Cell biology of the human thiamine transporter-1 (hTHTR1). Intracellular trafficking and membrane targeting mechanisms.

Ca2+ signaling in mouse cortical neurons studied by two-photon imaging and photoreleased inositol triphosphate.

Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy.

Photonics for biologists.

Video-rate confocal microscopy.

Real-time imaging of lymphocytes in vivo.

A stochastic view of lymphocyte motility and trafficking within the lymph node.

Buffer kinetics shape the spatiotemporal patterns of IP3-evoked Ca2+ signals.

Optical single-channel recording: imaging Ca2+ flux through individual N-type voltage-gated channels expressed in Xenopus oocytes.

T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node.

Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability.

Spatiotemporal patterning of IP3-mediated Ca2+ signals in Xenopus oocytes by Ca2+-binding proteins.

Early experiences with computed axial tomography colonography.

Zymogen granule exocytosis is characterized by long fusion pore openings and preservation of vesicle lipid identity.

Imaging the activity and localization of single voltage-gated Ca(2+) channels by total internal reflection fluorescence microscopy.

Imaging the single cell dynamics of CD4+ T cell activation by dendritic cells in lymph nodes.

Two phases of zymogen granule lifetime in mouse pancreas: ghost granules linger after exocytosis of contents.

Dynamic multiphoton imaging: a live view from cells to systems.

A model-independent algorithm to derive Ca2+ fluxes underlying local cytosolic Ca2+ transients.

Imaging single-channel calcium microdomains by total internal reflection microscopy.

Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers.

Optical single-channel recording by imaging Ca2+ flux through individual ion channels: theoretical considerations and limits to resolution.

Optical single-channel recording: imaging Ca2+ flux through individual ion channels with high temporal and spatial resolution.

Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells.

In situ characterization of CD4+ T cell behavior in mucosal and systemic lymphoid tissues during the induction of oral priming and tolerance.

"Optical patch-clamping": single-channel recording by imaging Ca2+ flux through individual muscle acetylcholine receptor channels.

Close encounters of the first and second kind: T-DC and T-B interactions in the lymph node.

Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses.

Analysis of puff dynamics in oocytes: interdependence of puff amplitude and interpuff interval.

Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice.

Plasmalemmal Ca2+ signaling in arterial smooth muscle: it's elementary!

Imaging Ca2+ signals in Xenopus oocytes.

Imaging the choreography of lymphocyte trafficking and the immune response.

Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo.

'Trigger' events precede calcium puffs in Xenopus oocytes.

The number and spatial distribution of IP3 receptors underlying calcium puffs in Xenopus oocytes.

Imaging single-channel calcium microdomains.

Psychoanalytic cyberspace, beyond psychology.

Loss of MMP-2 disrupts skeletal and craniofacial development and results in decreased bone mineralization, joint erosion and defects in osteoblast and osteoclast growth.

Enhanced ryanodine-mediated calcium release in mutant PS1-expressing Alzheimer's mouse models.

A kinetic model of single and clustered IP3 receptors in the absence of Ca2+ feedback.

Natural killer cells actively patrol peripheral lymph nodes forming stable conjugates to eliminate MHC-mismatched targets.

Ca2+ signals in CD4+ T cells during early contacts with antigen-bearing dendritic cells in lymph node.

Swingers: bonobos are celebrated as peace-loving, matriarchal, and sexually liberated. Are they?

Class IA phosphoinositide 3-kinase modulates basal lymphocyte motility in the lymph node.

Multi-dimensional resolution of elementary Ca2+ signals by simultaneous multi-focal imaging.

Mode switching is the major mechanism of ligand regulation of InsP3 receptor calcium release channels.

Choreography of cell motility and interaction dynamics imaged by two-photon microscopy in lymphoid organs.

SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production.

Localization of puff sites adjacent to the plasma membrane: functional and spatial characterization of Ca2+ signaling in SH-SY5Y cells utilizing membrane-permeant caged IP3.

Modeling Ca2+ feedback on a single inositol 1,4,5-trisphosphate receptor and its modulation by Ca2+ buffers.

SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production.

The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers.

Quantum dots for tracking dendritic cells and priming an immune response in vitro and in vivo.

Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block.

cADPR stimulates SERCA activity in Xenopus oocytes.

Imaging the quantal substructure of single IP3R channel activity during Ca2+ puffs in intact mammalian cells.

Chapter 16. Two-photon microscopy and multidimensional analysis of cell dynamics.

Acquisition of chemiluminescent signals from immunoblots with a digital single-lens reflex camera.

Ca(2+) puffs originate from preestablished stable clusters of inositol trisphosphate receptors.

NK cell patrolling and elimination of donor-derived dendritic cells favor indirect alloreactivity.

Calcium signaling and amyloid toxicity in Alzheimer disease.

Selective and site-specific mobilization of dermal dendritic cells and Langerhans cells by Th1- and Th2-polarizing adjuvants.

Modulation of endoplasmic reticulum Ca2+ store filling by cyclic ADP-ribose promotes inositol trisphosphate (IP3)-evoked Ca2+ signals.

A novel postsynaptic mechanism for heterosynaptic sharing of short-term plasticity.

Superresolution localization of single functional IP3R channels utilizing Ca2+ flux as a readout.

Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.

Recording single-channel activity of inositol trisphosphate receptors in intact cells with a microscope, not a patch clamp.

General approach to adoptive transfer and cell labeling for immunoimaging.

Induction of an immune response for imaging antigen-presenting cell/T-cell interactions.

In situ lymph node imaging.

In vivo lymph node imaging.

Immunoimaging: studying immune system dynamics using two-photon microscopy.

Active generation and propagation of Ca2+ signals within tunneling membrane nanotubes.

Enhanced ER Ca2+ store filling by overexpression of SERCA2b promotes IP3-evoked puffs.

Discursive social psychology now.

Subunit stoichiometry of human Orai1 and Orai3 channels in closed and open states.

Single-channel Ca(2+) imaging implicates Aβ1-42 amyloid pores in Alzheimer's disease pathology.

Timescales of IP(3)-Evoked Ca(2+) Spikes Emerge from Ca(2+) Puffs Only at the Cellular Level.

Toll-like receptor 4-activated B cells out-compete Toll-like receptor 9-activated B cells to establish peripheral immunological tolerance.

Multi-scale data-driven modeling and observation of calcium puffs.

The probability of triggering calcium puffs is linearly related to the number of inositol trisphosphate receptors in a cluster.

Cytosolic [Ca2+] regulation of InsP3-evoked puffs.

Structural and functional similarities of calcium homeostasis modulator 1 (CALHM1) ion channel with connexins, pannexins, and innexins.

Temperature dependence of IP3-mediated local and global Ca2+ signals.

Cytotoxicity of intracellular aβ42 amyloid oligomers involves Ca2+ release from the endoplasmic reticulum by stimulated production of inositol trisphosphate.

Orai1 function is essential for T cell homing to lymph nodes.

Three phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy.

Factors determining the recruitment of inositol trisphosphate receptor channels during calcium puffs.

Two-photon imaging of remyelination of spinal cord axons by engrafted neural precursor cells in a viral model of multiple sclerosis.

Termination of calcium puffs and coupled closings of inositol trisphosphate receptor channels.

An algorithm for automated detection, localization and measurement of local calcium signals from camera-based imaging.

Single-molecule tracking of inositol trisphosphate receptors reveals different motilities and distributions.

Fluorescence microscopy.

Modulation of elementary calcium release mediates a transition from puffs to waves in an IP3R cluster model.

Molecular Biophysics of Orai Store-Operated Ca(2+) Channels.

Imaging regulatory T cell dynamics and CTLA4-mediated suppression of T cell priming.