Results: Stress Granules Formation in Sodium Arsenite- and Vinorelbine-treated Cells
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Conclusion
Transkript
The overall goal of this workflow is to determine whether foci identified within the cytoplasm are bona fide stress granules which are RNA granules that play important roles in cell physiology. The main advantage of this workflow is that it tests
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Stress Granules (SGs) are nonmembranous cytoplasmic structures that form in cells exposed to a variety of stresses. SGs contain mRNAs, RNA-binding proteins, small ribosomal subunits, translation-related factors, and various cell signaling proteins. This protocol describes a workflow that uses several experimental approaches to detect, characterize, and quantify bona fide SGs.