Ileectomy, Anastomosis, and Ileectomy-induced Bile Overaccumulation Evaluation
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Results: Representative Ileectomy-induced Bile Overaccumulation Analysis
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Conclusion
Transkript
The overall goal of this surgery is to evaluate ileectomy-induced bile malabsorption, overaccumulation and toxicity in the mouse intestine. Diseases of the ileum as manifesting conditions such as Crohn's, cancer, autoimmune disorders or infection
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Small intestine-dependent bile acid reabsorption and feedback inhibition of hepatic bile acid synthesis is important for systemic homeostasis and health. In this study, we describe a mouse model for ileal resection to evaluate ileectomy-induced bile malabsorption, overaccumulation, and toxicity in mouse intestine.