Construction of the Markov State Model from Atomic Molecular Dynamics Simulations
6:26
Conducting Coarse-Grained Simulation to Sample Long-Time Dynamics
6:57
Results: Structure-Based Simulation and Sampling of Transcription Factor Protein Movements
8:45
Conclusion
Transkript
The goal of this protocol is to reveal structural dynamics of one-dimensional diffusion of protein along DNA, using a plant transcription factor WRKY domain protein as an exemplary system. The atomic simulations under the Markov state model constr
Bu içeriğe erişmek için giriş yapın veya ücretsiz denemenizi başlatın
The goal of this protocol is to reveal structural dynamics of one-dimensional diffusion of protein along DNA, using a plant transcription factor WRKY domain protein as an exemplary system. To do this, both atomistic and coarse-grained molecular dynamics simulations along with extensive computational samplings have been implemented.