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Methods Development for Blood Borne Macrophage Carriage of Nanoformulated Antiretroviral Drugs

DOI :

10.3791/2460-v

18:46 min

December 9th, 2010

December 9th, 2010

12,936 Views

1Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center

Nanoparticles of indinavir, ritonavir, efavirenz and atazanavir were manufactured using wet milling, homogenization and ultrasonication. These nanoformulations, collectively termed nanoformulated antiretroviral therapy (nanoART), assessed macrophage-based drug delivery. Monocyte-derived macrophage nanoART uptake, retention and sustained release were determined. These preliminary studies suggest the potential of nanoART for clinical use.

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Methods Development

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