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Intra-cardiac Side-Firing Light Catheter for Monitoring Cellular Metabolism using Transmural Absorbance Spectroscopy of Perfused Mammalian Hearts

DOI :

10.3791/58992-v

8:51 min

May 12th, 2019

May 12th, 2019

6,560 Views

1Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, 2Department of Biomedical Engineering, The George Washington University

Here we introduce a method for using an intra-ventricle optical catheter in perfused hearts to perform absorbance spectroscopy across the heart wall. The data obtained provides robust information on tissue oxygen tension as well as substrate utilization and membrane potential simultaneously with cardiac performance measures in this ubiquitous preparation.

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Intra cardiac Side Firing Light Catheter

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