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Therapeutic Gene Delivery and Transfection in Human Pancreatic Cancer Cells using Epidermal Growth Factor Receptor-targeted Gelatin Nanoparticles

DOI :

10.3791/3612-v

8:35 min

January 4th, 2012

January 4th, 2012

27,705 Views

1Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University

Type B gelatin-based engineered nanovectors system (GENS) was developed for systemic gene delivery and transfection in the treatment of pancreatic cancer. By modification with epidermal growth factor receptor (EGFR) specific peptide on the surface of nanparticles, they could target on EGFR receptor and release plasmid under reducing environment, such as high intracellular glutathione concentrations.

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Therapeutic Gene Delivery

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