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Rapid Determination of the Thermal Nociceptive Threshold in Diabetic Rats

DOI :

10.3791/3785-v

May 17th, 2012

May 17th, 2012

27,127 Views

1Department of Pharmacology and Toxicology, Wright State University, 2Human Movement Laboratory, Universidade São Judas Tadeu

Here, we describe a rapid reliable and simple procedure to determine the lowest temperature at which rats or mice show nocifensive behavior, i.e. the thermal nociceptive threshold (TNT). This method applies a slowly increasing thermal stimulus allowing precise and reproducible estimation of TNTs with minimum, if any, stress to the animals.

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Thermal Nociceptive Threshold

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