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Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

DOI :

10.3791/51264-v

7:23 min

July 29th, 2014

July 29th, 2014

32,486 Views

1Biotechnology and Cellular Signalling, UMR 7242 CNRS, Université de Strasbourg

We describe a protocol to examine the development of opioid-induced hyperalgesia and tolerance in mice. Based on the measurement of thermal and mechanical nociceptive responses of naïve and morphine-treated animals, it allows to quantify the increase in pain sensitivity (hyperalgesia) and decrease in analgesia (tolerance) associated with chronic opiate administration.

Tags

Opioid induced Hyperalgesia

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