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Rat Mesentery Exteriorization: A Model for Investigating the Cellular Dynamics Involved in Angiogenesis

DOI :

10.3791/3954-v

12:29 min

May 20th, 2012

May 20th, 2012

18,651 Views

1Department of Biomedical Engineering, Tulane University, 2Department of Biomedical Engineering, University of Virginia , 3Center for Stem Cell Research and Regenerative Medicine, Tulane University

This article describes a simple model for stimulating angiogenesis in the rat mesentery. The model produces dramatic increases in capillary sprouting, vascular area and vascular density over a relatively short time course in a tissue that allows en face visualization of entire microvascular networks down to the single cell level.

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Rat Mesentery Exteriorization

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