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High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels

DOI :

10.3791/4209-v

January 27th, 2013

January 27th, 2013

14,777 Views

1Department of Pharmacology, Vanderbilt University School of Medicine, 2Department of Anesthesiology, Vanderbilt University School of Medicine, 3Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine

Methods for developing and validating a quantitative fluorescence assay for measuring the activity of inward rectifier potassium (Kir) channels for high-throughput compound screening is presented.

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High throughput Screening

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