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Formation of Human Prostate Epithelium Using Tissue Recombination of Rodent Urogenital Sinus Mesenchyme and Human Stem Cells

DOI :

10.3791/50327-v

June 22nd, 2013

June 22nd, 2013

13,437 Views

1Department of Surgery, Section of Urology, University of Chicago, 2Committee on Cancer Biology, University of Chicago

To unravel the earliest molecular mechanisms underlying prostate cancer initiation, novel and innovative human model systems and approaches are desperately needed. The potential of pre-prostatic urogenital sinus mesenchyme (UGSM) to induce pluripotent stem cell populations to form human prostate epithelium is a powerful experimental tool in prostate research.

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