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An Orthotopic Murine Model of Human Prostate Cancer Metastasis

DOI :

10.3791/50873-v

6:48 min

September 18th, 2013

September 18th, 2013

34,020 Views

1Department of Medicine, Northwestern University, 2Robert H. Lurie Cancer Center, Northwestern University, 3Center for Molecular Innovation and Drug Discovery, Northwestern University

This orthotopic model of human prostate cancer allows for quantification of tumor size, circulating tumor cells, and formation of distinct metastasis to the lung. As cells must escape the primary organ, enter the blood stream, and implant into a secondary site, this model effectively recapitulates the scenario in humans.

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Orthotopic Implantation Model

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