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JoVE Journal

Medicine

This content is Open Access.

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

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06:48 min

September 18th, 2013

September 18th, 2013

34,574 Views

0:05

Title

1:32

Orthotopic Implantation of Human Prostate Cancer Cells

2:35

Necropsy Procedures

3:39

Results: Identification and Quantification of Metastases in a Murine Human Pancreatic Cancer Model

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Conclusion

This orthotopic model of human prostate cancer allows for quantification of tumor size, circulating tumor cells, and formation of distinct metastasis to the lung. As cells must escape the primary organ, enter the blood stream, and implant into a secondary site, this model effectively recapitulates the scenario in humans.

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