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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

DOI :

10.3791/50766-v

December 10th, 2013

December 10th, 2013

7,726 Views

1Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud university medical center

Human respiratory syncytial virus (HRSV) can cause severe bronchiolitis in young infants. Part of the pathogenesis of severe HRSV disease is caused by the host immune response. Stimulation of primary human immune cells with HRSV provides a fast and reproducible model system to study activation of inflammatory pathways and infection.

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In Vitro Model

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