Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis

10.0K Views

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09:28 min

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May 12th, 2019

DOI :

10.3791/59223-v

May 12th, 2019

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Ravan Moret¹, Linh Hellmers¹, Xin Zhang¹, Jessie Gills², Nathan Hite³, Aaron Klinger³, Grace A. Maresh¹, Daniel Canter²^,⁴, Stephen Bardot²^,⁴, David A Margolin³^,⁴, Li Li¹^,⁴

¹Laboratory of Translational Cancer Research, Institute for Translational Research, Ochsner Clinic Foundation, ²Department of Urology, Ochsner Clinic Foundation, ³Department of Colon and Rectal Surgery, Ochsner Clinic Foundation, ⁴Ochsner Clinical School, University of Queensland, School of Medicine

Summary

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Orthotopic Xenograft Models

Human Urothelial Cell Carcinoma

Patient derived Tumors

Deoxyribonuclease Type 1

Chapters in this video

0:04

Title

0:55

Tumor Enzymatic Digestion

2:54

UCC Mouse Model

4:48

CRC Mouse Model

6:02

Bioluminescent Imaging, Organ Harvesting and Evaluation

6:55

Results: Xenograft Tumor Analysis and Comparison with Primary Patient Tumors

8:44

Conclusion

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