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Measuring Spinal Presynaptic Inhibition in Mice By Dorsal Root Potential Recording In Vivo

DOI :

10.3791/51473-v

March 29th, 2014

March 29th, 2014

13,689 Views

1Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany, 2Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany

GABAergic presynaptic inhibition is a powerful inhibitory mechanism in the spinal cord important for motor and sensory signal integration in spinal cord networks. Underlying primary afferent depolarization can be measured by recording of dorsal root potentials (DRP). Here we demonstrate a method of in vivo recording of DRP in mice.

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Measuring Spinal Presynaptic Inhibition

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