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Protocol for Studying Extinction of Conditioned Fear in Naturally Cycling Female Rats

DOI :

10.3791/52202-v

February 23rd, 2015

February 23rd, 2015

12,919 Views

1Department of Psychiatry, Massachusetts General Hospital, 2Harvard Medical School

Gonadal hormones such as estrogen modulate memory formation in a number of experimental paradigms including fear extinction memory. This protocol describes a set of methods for investigating the influence of gonadal hormones specifically during extinction in naturally cycling females, including estrous cycle monitoring and exogenous estrogen administration.

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