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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

DOI :

10.3791/52441-v

October 26th, 2015

October 26th, 2015

11,033 Views

1Department of Drug Discovery and Biomedical Sciences, University of South Carolina

We describe implementation of the REPLACE strategy for targeting protein-protein interactions. REPLACE is an iterative strategy involving synthetic and computational approaches for the conversion of optimized peptidic inhibitors into drug like molecules.

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Keywords Protein protein Interactions

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