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Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin

DOI :

10.3791/52679-v

8:57 min

March 26th, 2015

March 26th, 2015

26,299 Views

1Department of Clinical Neurosciences, Hotchkiss Brain Institute at University of Calgary, 2Department of Oncology, Hotchkiss Brain Institute at University of Calgary

Demyelinating diseases can be modeled in animals by focal application of lysolecithin into the CNS. A single injection of lysolecithin into mouse spinal cord produces a lesion that spontaneously repairs over time. The goal is to study factors involved in de- and remyelination, and to test agents for enhancing repair.

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Keywords Experimental Demyelination

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