Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines

4.6K Views

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09:46 min

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September 21st, 2021

DOI :

10.3791/57879-v

September 21st, 2021

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Muammer Üçal*¹, Michaela Tanja Haindl*², Milena Z. Adzemovic³, Manuel Zeitelhofer⁴, Ute Schaefer¹, Franz Fazekas², Sonja Hochmeister²

¹Research Unit of Experimental Neurotraumatology, Department of Neurosurgery, Medical University Graz, ²Department of Neurology, Medical University Graz, ³Centre for Molecular Medicine, Department of Clinical Neuroscience, Karolinska Institutet, ⁴Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet

Summary

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Keywords Rat

Cerebral Cortex

Demyelination

Pro inflammatory Cytokines

Multiple Sclerosis

Catheter Implantation

Stereotactic Surgery

Cortical Inflammation

Gray Matter Demyelination

Anchor Screws

Chapters in this video

0:05

Introduction

1:15

Catheter Implantation

4:39

Immunization

5:57

Intracerebral Cytokine Injection

7:16

Results: PLP Immunoreactivity in Coronal Brain Sections

8:52

Conclusion

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